Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters
Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, exa...
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Series: | Mediators of Inflammation |
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doaj-6025866631454688a92189fc6fa669462020-11-24T23:21:58ZengHindawi LimitedMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/967067967067Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related ParametersK. Suárez-Álvarez0L. Solís-Lozano1S. Leon-Cabrera2A. González-Chávez3G. Gómez-Hernández4M. S. Quiñones-Álvarez5A. E. Serralde-Zúñiga6J. Hernández-Ruiz7J. Ramírez-Velásquez8F. J. Galindo-González9J. C. Zavala-Castillo10M. A. De León-Nava11G. Robles-Díaz12G. Escobedo13Unidad de Medicina Experimental, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, MexicoUnidad de Medicina Experimental, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, MexicoDepartamento de Biología de la Reproducción y Clínica de Desórdenes de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, México D. F. 09340, MexicoServicio de Medicina Interna, Hospital General de México, México D. F. 06726, MexicoServicio de Banco de Sangre, Hospital General de México, México D. F. 06726, MexicoServicio de Medicina Interna, Hospital General de México, México D. F. 06726, MexicoFundación Mexicana para la Salud, México D. F. 14610, MexicoUnidad de Medicina Experimental, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, MexicoServicio de Cirugía General, Hospital General de México “Dr. Eduardo Liceaga”, México, 06726 DF, MexicoServicio de Cirugía General, Hospital General de México “Dr. Eduardo Liceaga”, México, 06726 DF, MexicoServicio de Cirugía General, Hospital General de México “Dr. Eduardo Liceaga”, México, 06726 DF, MexicoUnidad de Desarrollo Biomédico, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Ensenada 22860, Baja California, MexicoLaboratorio de Hígado, Páncreas y Motilidad, Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, MexicoUnidad de Medicina Experimental, Hospital General de México “Dr. Eduardo Liceaga”, México D. F. 06726, MexicoInterleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r=0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r=0.4481), body fat percentage (r=0.5625), serum glucose (r=0.3158), triglyceride (r=0.3714), and TNF-α (r=0.4717). Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans.http://dx.doi.org/10.1155/2013/967067 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
K. Suárez-Álvarez L. Solís-Lozano S. Leon-Cabrera A. González-Chávez G. Gómez-Hernández M. S. Quiñones-Álvarez A. E. Serralde-Zúñiga J. Hernández-Ruiz J. Ramírez-Velásquez F. J. Galindo-González J. C. Zavala-Castillo M. A. De León-Nava G. Robles-Díaz G. Escobedo |
spellingShingle |
K. Suárez-Álvarez L. Solís-Lozano S. Leon-Cabrera A. González-Chávez G. Gómez-Hernández M. S. Quiñones-Álvarez A. E. Serralde-Zúñiga J. Hernández-Ruiz J. Ramírez-Velásquez F. J. Galindo-González J. C. Zavala-Castillo M. A. De León-Nava G. Robles-Díaz G. Escobedo Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters Mediators of Inflammation |
author_facet |
K. Suárez-Álvarez L. Solís-Lozano S. Leon-Cabrera A. González-Chávez G. Gómez-Hernández M. S. Quiñones-Álvarez A. E. Serralde-Zúñiga J. Hernández-Ruiz J. Ramírez-Velásquez F. J. Galindo-González J. C. Zavala-Castillo M. A. De León-Nava G. Robles-Díaz G. Escobedo |
author_sort |
K. Suárez-Álvarez |
title |
Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters |
title_short |
Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters |
title_full |
Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters |
title_fullStr |
Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters |
title_full_unstemmed |
Serum IL-12 Is Increased in Mexican Obese Subjects and Associated with Low-Grade Inflammation and Obesity-Related Parameters |
title_sort |
serum il-12 is increased in mexican obese subjects and associated with low-grade inflammation and obesity-related parameters |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2013-01-01 |
description |
Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r=0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r=0.4481), body fat percentage (r=0.5625), serum glucose (r=0.3158), triglyceride (r=0.3714), and TNF-α (r=0.4717). Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans. |
url |
http://dx.doi.org/10.1155/2013/967067 |
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