The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis

The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis

Abstract Background/aim N-Acetylcysteine (NAC) demonstrates applications in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD). COPD is often characterized by fibrosis of the small airways. This study aims at investigating the physiological mechanisms by which NAC might m...

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Bibliographic Details
Main Authors: Lanlan Zhu, Fei Xu, Xiuhua Kang, Jing Zhou, Qinqin Yao, Yang Lin, Wei Zhang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Medicine
Subjects:
N-Acetylcysteine
Chronic obstructive pulmonary disease
Pulmonary fibrosis
Epithelial-mesenchymal transition
Immune response
VWF
Online Access:https://doi.org/10.1186/s10020-021-00342-y

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