First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region

We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since w...

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Main Authors:	Bourema Kouriba, Angela Dürr, Alexandra Rehn, Abdoul Karim Sangaré, Brehima Y. Traoré, Malena S. Bestehorn-Willmann, Judicael Ouedraogo, Asli Heitzer, Elisabeth Sogodogo, Abderrhamane Maiga, Mathias C. Walter, Fee Zimmermann, Roman Wölfel, Markus H. Antwerpen
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Viruses
Subjects:	SARS-CoV-2 phylogenetic analysis Mali
Online Access:	https://www.mdpi.com/1999-4915/12/11/1251

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spelling	doaj-602d1d698613445db2dc64c094a9f0392020-11-25T04:06:03ZengMDPI AGViruses1999-49152020-11-01121251125110.3390/v12111251First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel RegionBourema Kouriba0Angela Dürr1Alexandra Rehn2Abdoul Karim Sangaré3Brehima Y. Traoré4Malena S. Bestehorn-Willmann5Judicael Ouedraogo6Asli Heitzer7Elisabeth Sogodogo8Abderrhamane Maiga9Mathias C. Walter10Fee Zimmermann11Roman Wölfel12Markus H. Antwerpen13Centre d’Infectiologie Charles Mérieux du Mali, Bamako BPE2283, MaliBundeswehr Institute of Microbiology, D-80937 Munich, GermanyBundeswehr Institute of Microbiology, D-80937 Munich, GermanyCentre d’Infectiologie Charles Mérieux du Mali, Bamako BPE2283, MaliCentre d’Infectiologie Charles Mérieux du Mali, Bamako BPE2283, MaliBundeswehr Institute of Microbiology, D-80937 Munich, GermanyCentre d’Infectiologie Charles Mérieux du Mali, Bamako BPE2283, MaliBundeswehr Institute of Microbiology, D-80937 Munich, GermanyCentre d’Infectiologie Charles Mérieux du Mali, Bamako BPE2283, MaliCentre d’Infectiologie Charles Mérieux du Mali, Bamako BPE2283, MaliBundeswehr Institute of Microbiology, D-80937 Munich, GermanyBundeswehr Institute of Microbiology, D-80937 Munich, GermanyBundeswehr Institute of Microbiology, D-80937 Munich, GermanyBundeswehr Institute of Microbiology, D-80937 Munich, GermanyWe are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequencing (WGS) data is very crucial to understand the spreading dynamics of the ongoing pandemic, but only limited sequencing data is available from the Sahel region to date, we have focused our efforts on generating the first Malian sequencing data available. Screening 217 Malian patient samples for the presence of SARS-CoV-2 resulted in 38 positive isolates, from which 21 whole genome sequences were generated. Our analysis shows that both the early A (19B) and the later observed B (20A/C) clade are present in Mali, indicating multiple and independent introductions of SARS-CoV-2 to the Sahel region.https://www.mdpi.com/1999-4915/12/11/1251SARS-CoV-2phylogenetic analysisMali
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bourema Kouriba Angela Dürr Alexandra Rehn Abdoul Karim Sangaré Brehima Y. Traoré Malena S. Bestehorn-Willmann Judicael Ouedraogo Asli Heitzer Elisabeth Sogodogo Abderrhamane Maiga Mathias C. Walter Fee Zimmermann Roman Wölfel Markus H. Antwerpen
spellingShingle	Bourema Kouriba Angela Dürr Alexandra Rehn Abdoul Karim Sangaré Brehima Y. Traoré Malena S. Bestehorn-Willmann Judicael Ouedraogo Asli Heitzer Elisabeth Sogodogo Abderrhamane Maiga Mathias C. Walter Fee Zimmermann Roman Wölfel Markus H. Antwerpen First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region Viruses SARS-CoV-2 phylogenetic analysis Mali
author_facet	Bourema Kouriba Angela Dürr Alexandra Rehn Abdoul Karim Sangaré Brehima Y. Traoré Malena S. Bestehorn-Willmann Judicael Ouedraogo Asli Heitzer Elisabeth Sogodogo Abderrhamane Maiga Mathias C. Walter Fee Zimmermann Roman Wölfel Markus H. Antwerpen
author_sort	Bourema Kouriba
title	First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region
title_short	First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region
title_full	First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region
title_fullStr	First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region
title_full_unstemmed	First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region
title_sort	first phylogenetic analysis of malian sars-cov-2 sequences provides molecular insights into the genomic diversity of the sahel region
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2020-11-01
description	We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequencing (WGS) data is very crucial to understand the spreading dynamics of the ongoing pandemic, but only limited sequencing data is available from the Sahel region to date, we have focused our efforts on generating the first Malian sequencing data available. Screening 217 Malian patient samples for the presence of SARS-CoV-2 resulted in 38 positive isolates, from which 21 whole genome sequences were generated. Our analysis shows that both the early A (19B) and the later observed B (20A/C) clade are present in Mali, indicating multiple and independent introductions of SARS-CoV-2 to the Sahel region.
topic	SARS-CoV-2 phylogenetic analysis Mali
url	https://www.mdpi.com/1999-4915/12/11/1251
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First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region

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