miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity

miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity

Huntington’s disease (HD) is an autosomal-dominant brain disorder caused by mutant huntingtin (mHtt). Although the detailed mechanisms remain unclear, the mutational expansion of polyglutamine in mHtt is proposed to induce protein aggregates and neuronal toxicity. Previous studies have shown that th...

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Bibliographic Details
Main Authors: Ching-Chi Chang, Sing-Hua Tsou, Wei-Jen Chen, Ying-Jui Ho, Hui-Chih Hung, Guang-Yaw Liu, Sandeep Kumar Singh, Hsin-Hua Li, Chih-Li Lin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
Huntington’s disease
insulin signaling
mitophagy
miR-302
Online Access:https://www.mdpi.com/1422-0067/22/16/8424

Internet

https://www.mdpi.com/1422-0067/22/16/8424

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