Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to...
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| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14112-2 |
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doaj-603dfe4ffed14153a4ca1bede6c41d3e2021-05-11T08:00:32ZengNature Publishing GroupNature Communications2041-17232020-01-0111111710.1038/s41467-019-14112-2Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasisTom Sidwell0Yang Liao1Alexandra L. Garnham2Ajithkumar Vasanthakumar3Renee Gloury4Jonas Blume5Peggy P. Teh6David Chisanga7Christoph Thelemann8Fabian de Labastida Rivera9Christian R. Engwerda10Lynn Corcoran11Kohei Kometani12Tomohiro Kurosaki13Gordon K. Smyth14Wei Shi15Axel Kallies16Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of MelbourneBioinformatics Division, Walter and Eliza Hall Institute of Medical ResearchBioinformatics Division, Walter and Eliza Hall Institute of Medical ResearchDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of MelbourneDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of MelbourneDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of MelbourneDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of MelbourneBioinformatics Division, Walter and Eliza Hall Institute of Medical ResearchMolecular Immunology, Walter and Eliza Hall Institute of Medical ResearchQIMR Berghofer Medical Research InstituteQIMR Berghofer Medical Research InstituteMolecular Immunology, Walter and Eliza Hall Institute of Medical ResearchLaboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS)Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS)Bioinformatics Division, Walter and Eliza Hall Institute of Medical ResearchBioinformatics Division, Walter and Eliza Hall Institute of Medical ResearchDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of MelbourneThe transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling.https://doi.org/10.1038/s41467-019-14112-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tom Sidwell Yang Liao Alexandra L. Garnham Ajithkumar Vasanthakumar Renee Gloury Jonas Blume Peggy P. Teh David Chisanga Christoph Thelemann Fabian de Labastida Rivera Christian R. Engwerda Lynn Corcoran Kohei Kometani Tomohiro Kurosaki Gordon K. Smyth Wei Shi Axel Kallies |
| spellingShingle |
Tom Sidwell Yang Liao Alexandra L. Garnham Ajithkumar Vasanthakumar Renee Gloury Jonas Blume Peggy P. Teh David Chisanga Christoph Thelemann Fabian de Labastida Rivera Christian R. Engwerda Lynn Corcoran Kohei Kometani Tomohiro Kurosaki Gordon K. Smyth Wei Shi Axel Kallies Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis Nature Communications |
| author_facet |
Tom Sidwell Yang Liao Alexandra L. Garnham Ajithkumar Vasanthakumar Renee Gloury Jonas Blume Peggy P. Teh David Chisanga Christoph Thelemann Fabian de Labastida Rivera Christian R. Engwerda Lynn Corcoran Kohei Kometani Tomohiro Kurosaki Gordon K. Smyth Wei Shi Axel Kallies |
| author_sort |
Tom Sidwell |
| title |
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis |
| title_short |
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis |
| title_full |
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis |
| title_fullStr |
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis |
| title_full_unstemmed |
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis |
| title_sort |
attenuation of tcr-induced transcription by bach2 controls regulatory t cell differentiation and homeostasis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling. |
| url |
https://doi.org/10.1038/s41467-019-14112-2 |
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