Local control of striatal dopamine release
The mesolimbic and nigrostriatal dopamine (DA) systems play a key role in the physiology of reward seeking, motivation and motor control. Importantly, they are also involved in the pathophysiology of Parkinson’s and Huntington’s disease, schizophrenia and addiction. Control of DA release in the stri...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-05-01
|
Series: | Frontiers in Behavioral Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00188/full |
id |
doaj-604527a230174cef9f38d88a1afd9685 |
---|---|
record_format |
Article |
spelling |
doaj-604527a230174cef9f38d88a1afd96852020-11-24T20:52:28ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-05-01810.3389/fnbeh.2014.0018888747Local control of striatal dopamine releaseRoger eCachope0Roger eCachope1Joseph F Cheer2Joseph F Cheer3CHDI Foundation Inc./CHDI Management Inc.University of Maryland School of MedicineUniversity of Maryland School of MedicineUniversity of Maryland School of MedicineThe mesolimbic and nigrostriatal dopamine (DA) systems play a key role in the physiology of reward seeking, motivation and motor control. Importantly, they are also involved in the pathophysiology of Parkinson’s and Huntington’s disease, schizophrenia and addiction. Control of DA release in the striatum is tightly linked to firing of DA neurons in the ventral tegmental area (VTA) and the substantia nigra (SN). However, local influences in the striatum affect release by exerting their action directly on axon terminals. For example, endogenous glutamatergic and cholinergic activity is sufficient to trigger striatal DA release independently of cell body firing. Recent developments involving genetic manipulation, pharmacological selectivity or selective stimulation have allowed for better characterization of these phenomena. Such termino-terminal forms of control of DA release transform considerably our understanding of the mesolimbic and nigrostriatal systems, and have strong implications as potential mechanisms to modify impaired control of DA release in the diseased brain. Here, we review these and related mechanisms and their implications in the physiology of ascending DA systems.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00188/fullAcetylcholineDopamineGlutamateStriatumvolume transmissionoptogenetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roger eCachope Roger eCachope Joseph F Cheer Joseph F Cheer |
spellingShingle |
Roger eCachope Roger eCachope Joseph F Cheer Joseph F Cheer Local control of striatal dopamine release Frontiers in Behavioral Neuroscience Acetylcholine Dopamine Glutamate Striatum volume transmission optogenetics |
author_facet |
Roger eCachope Roger eCachope Joseph F Cheer Joseph F Cheer |
author_sort |
Roger eCachope |
title |
Local control of striatal dopamine release |
title_short |
Local control of striatal dopamine release |
title_full |
Local control of striatal dopamine release |
title_fullStr |
Local control of striatal dopamine release |
title_full_unstemmed |
Local control of striatal dopamine release |
title_sort |
local control of striatal dopamine release |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2014-05-01 |
description |
The mesolimbic and nigrostriatal dopamine (DA) systems play a key role in the physiology of reward seeking, motivation and motor control. Importantly, they are also involved in the pathophysiology of Parkinson’s and Huntington’s disease, schizophrenia and addiction. Control of DA release in the striatum is tightly linked to firing of DA neurons in the ventral tegmental area (VTA) and the substantia nigra (SN). However, local influences in the striatum affect release by exerting their action directly on axon terminals. For example, endogenous glutamatergic and cholinergic activity is sufficient to trigger striatal DA release independently of cell body firing. Recent developments involving genetic manipulation, pharmacological selectivity or selective stimulation have allowed for better characterization of these phenomena. Such termino-terminal forms of control of DA release transform considerably our understanding of the mesolimbic and nigrostriatal systems, and have strong implications as potential mechanisms to modify impaired control of DA release in the diseased brain. Here, we review these and related mechanisms and their implications in the physiology of ascending DA systems. |
topic |
Acetylcholine Dopamine Glutamate Striatum volume transmission optogenetics |
url |
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00188/full |
work_keys_str_mv |
AT rogerecachope localcontrolofstriataldopaminerelease AT rogerecachope localcontrolofstriataldopaminerelease AT josephfcheer localcontrolofstriataldopaminerelease AT josephfcheer localcontrolofstriataldopaminerelease |
_version_ |
1716799539898220544 |