The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients

• Main Authors: Čolak Emina, Dimitrijević-Srećković Vesna, Đorđević Predrag B., Stanković Sanja, Majkić-Singh Nada, Lalić Katarina, Lalić Nebojša
• Format: Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 2007-01-01
• Series: Journal of Medical Biochemistry
• Subjects: oxidative stress; antioxidant defense; type 2 diabetes mellitus; cardiovascular complications
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470701010C.pdf
• ISSN: 1452-8258; 1452-8266

It is well established that type 2 diabetes mellitus is associated with highly increased risk of coronary heart disease, cardiovascular disease (CVD), and total mortality. CVD is the leading cause of death of people with diabetes. The aim of our study was to test the effect of type and duration of cardiovascular complications on antioxidant parameter values: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status in patients with type 2 diabetes mellitus and manifested cardiovascular complications. Out of 100 subjects included in the study, 69 subjects were type 2 diabetic patients with cardiovascular complications and 31 age-matched controls. Statistical data processing revealed significantly lower antioxidant defense (p<0.001) in patients with type 2 diabetes and cardiovascular complications manifested as coronary artery disease (CAD), hypertension (HTA) and myocardial infarction experienced in the previous 8 years (AMI). The type 2 diabetics with longer history of diabetes and coronary artery disease had higher fasting glucose values, higher GR activity, but lower TAS and SOD activity (p<0.05). Fasting glucose levels were in negative correlation with SOD and GPx activities in the subgroups of diabetics with severe cardiovascular complications (CAD+AMI CAD+AMI+ HTA) (p<0.05).