The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients
It is well established that type 2 diabetes mellitus is associated with highly increased risk of coronary heart disease, cardiovascular disease (CVD), and total mortality. CVD is the leading cause of death of people with diabetes. The aim of our study was to test the effect of type and duration of c...
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2007-01-01
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doaj-605f0dc9478443b5abd04a051ff77fc22020-11-25T02:07:53ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662007-01-0126110160354-34470701010CThe influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patientsČolak Emina0Dimitrijević-Srećković Vesna1https://orcid.org/0000-0001-5763-5494Đorđević Predrag B.2Stanković Sanja3https://orcid.org/0000-0003-3142-9902Majkić-Singh Nada4Lalić Katarina5https://orcid.org/0000-0002-8070-1899Lalić Nebojša6Institute of Medical Biochemistry, Clinical Center of Serbia, BelgradeInstitute of Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Serbia, BelgradeInstitute of Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Serbia, BelgradeInstitute of Medical Biochemistry, Clinical Center of Serbia, BelgradeInstitute of Medical Biochemistry, Clinical Center of Serbia, BelgradeInstitute of Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Serbia, BelgradeInstitute of Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Serbia, BelgradeIt is well established that type 2 diabetes mellitus is associated with highly increased risk of coronary heart disease, cardiovascular disease (CVD), and total mortality. CVD is the leading cause of death of people with diabetes. The aim of our study was to test the effect of type and duration of cardiovascular complications on antioxidant parameter values: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status in patients with type 2 diabetes mellitus and manifested cardiovascular complications. Out of 100 subjects included in the study, 69 subjects were type 2 diabetic patients with cardiovascular complications and 31 age-matched controls. Statistical data processing revealed significantly lower antioxidant defense (p<0.001) in patients with type 2 diabetes and cardiovascular complications manifested as coronary artery disease (CAD), hypertension (HTA) and myocardial infarction experienced in the previous 8 years (AMI). The type 2 diabetics with longer history of diabetes and coronary artery disease had higher fasting glucose values, higher GR activity, but lower TAS and SOD activity (p<0.05). Fasting glucose levels were in negative correlation with SOD and GPx activities in the subgroups of diabetics with severe cardiovascular complications (CAD+AMI CAD+AMI+ HTA) (p<0.05).https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470701010C.pdfoxidative stressantioxidant defensetype 2 diabetes mellituscardiovascular complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Čolak Emina Dimitrijević-Srećković Vesna Đorđević Predrag B. Stanković Sanja Majkić-Singh Nada Lalić Katarina Lalić Nebojša |
spellingShingle |
Čolak Emina Dimitrijević-Srećković Vesna Đorđević Predrag B. Stanković Sanja Majkić-Singh Nada Lalić Katarina Lalić Nebojša The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients Journal of Medical Biochemistry oxidative stress antioxidant defense type 2 diabetes mellitus cardiovascular complications |
author_facet |
Čolak Emina Dimitrijević-Srećković Vesna Đorđević Predrag B. Stanković Sanja Majkić-Singh Nada Lalić Katarina Lalić Nebojša |
author_sort |
Čolak Emina |
title |
The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients |
title_short |
The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients |
title_full |
The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients |
title_fullStr |
The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients |
title_full_unstemmed |
The influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients |
title_sort |
influence of type and duration of cardiovascular complications on antioxidative parameter values in type 2 diabetic patients |
publisher |
Society of Medical Biochemists of Serbia, Belgrade |
series |
Journal of Medical Biochemistry |
issn |
1452-8258 1452-8266 |
publishDate |
2007-01-01 |
description |
It is well established that type 2 diabetes mellitus is associated with highly increased risk of coronary heart disease, cardiovascular disease (CVD), and total mortality. CVD is the leading cause of death of people with diabetes. The aim of our study was to test the effect of type and duration of cardiovascular complications on antioxidant parameter values: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status in patients with type 2 diabetes mellitus and manifested cardiovascular complications. Out of 100 subjects included in the study, 69 subjects were type 2 diabetic patients with cardiovascular complications and 31 age-matched controls. Statistical data processing revealed significantly lower antioxidant defense (p<0.001) in patients with type 2 diabetes and cardiovascular complications manifested as coronary artery disease (CAD), hypertension (HTA) and myocardial infarction experienced in the previous 8 years (AMI). The type 2 diabetics with longer history of diabetes and coronary artery disease had higher fasting glucose values, higher GR activity, but lower TAS and SOD activity (p<0.05). Fasting glucose levels were in negative correlation with SOD and GPx activities in the subgroups of diabetics with severe cardiovascular complications (CAD+AMI CAD+AMI+ HTA) (p<0.05). |
topic |
oxidative stress antioxidant defense type 2 diabetes mellitus cardiovascular complications |
url |
https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2007/0354-34470701010C.pdf |
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