Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5.

Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5.

p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse brain via impaired neuronal migration, which may...

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Bibliographic Details
Main Authors: Shunsuke Takada, Keiko Mizuno, Taro Saito, Akiko Asada, Karl Peter Giese, Shin-Ichi Hisanaga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4607440?pdf=render

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