Mast Cell-Mediated Mechanisms of Nociception
Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic respon...
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doaj-60699725767740cd88dcbc3c495e2fb72020-11-25T00:59:51ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-011612290692909210.3390/ijms161226151ijms161226151Mast Cell-Mediated Mechanisms of NociceptionAnupam Aich0Lawrence B. Afrin1Kalpna Gupta2Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USAVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USAVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USAMast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner.http://www.mdpi.com/1422-0067/16/12/26151mast cellspainmigrainecytokinescancerinflammationsubstance Ptryptasehyperalgesiasickle cell disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anupam Aich Lawrence B. Afrin Kalpna Gupta |
spellingShingle |
Anupam Aich Lawrence B. Afrin Kalpna Gupta Mast Cell-Mediated Mechanisms of Nociception International Journal of Molecular Sciences mast cells pain migraine cytokines cancer inflammation substance P tryptase hyperalgesia sickle cell disease |
author_facet |
Anupam Aich Lawrence B. Afrin Kalpna Gupta |
author_sort |
Anupam Aich |
title |
Mast Cell-Mediated Mechanisms of Nociception |
title_short |
Mast Cell-Mediated Mechanisms of Nociception |
title_full |
Mast Cell-Mediated Mechanisms of Nociception |
title_fullStr |
Mast Cell-Mediated Mechanisms of Nociception |
title_full_unstemmed |
Mast Cell-Mediated Mechanisms of Nociception |
title_sort |
mast cell-mediated mechanisms of nociception |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-12-01 |
description |
Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner. |
topic |
mast cells pain migraine cytokines cancer inflammation substance P tryptase hyperalgesia sickle cell disease |
url |
http://www.mdpi.com/1422-0067/16/12/26151 |
work_keys_str_mv |
AT anupamaich mastcellmediatedmechanismsofnociception AT lawrencebafrin mastcellmediatedmechanismsofnociception AT kalpnagupta mastcellmediatedmechanismsofnociception |
_version_ |
1725215640675942400 |