Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes

Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes

The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.

Bibliographic Details
Main Authors: Andreas Porse, Leonie J. Jahn, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15080-8
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spelling doaj-606e123abcb44a1d8324f2a0a0dd11902021-05-11T09:00:54ZengNature Publishing GroupNature Communications2041-17232020-03-011111910.1038/s41467-020-15080-8Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genesAndreas Porse0Leonie J. Jahn1Mostafa M. H. Ellabaan2Morten O. A. Sommer3Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkNovo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkNovo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkNovo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.https://doi.org/10.1038/s41467-020-15080-8
collection DOAJ
language English
format Article
sources DOAJ
author Andreas Porse
Leonie J. Jahn
Mostafa M. H. Ellabaan
Morten O. A. Sommer
spellingShingle Andreas Porse
Leonie J. Jahn
Mostafa M. H. Ellabaan
Morten O. A. Sommer
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
Nature Communications
author_facet Andreas Porse
Leonie J. Jahn
Mostafa M. H. Ellabaan
Morten O. A. Sommer
author_sort Andreas Porse
title Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_short Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_full Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_fullStr Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_full_unstemmed Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_sort dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-03-01
description The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.
url https://doi.org/10.1038/s41467-020-15080-8
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AT mostafamhellabaan dominantresistanceandnegativeepistasiscanlimitthecoselectionofdenovoresistancemutationsandantibioticresistancegenes
AT mortenoasommer dominantresistanceandnegativeepistasiscanlimitthecoselectionofdenovoresistancemutationsandantibioticresistancegenes
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