Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.
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Nature Publishing Group
2020-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15080-8 |
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doaj-606e123abcb44a1d8324f2a0a0dd11902021-05-11T09:00:54ZengNature Publishing GroupNature Communications2041-17232020-03-011111910.1038/s41467-020-15080-8Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genesAndreas Porse0Leonie J. Jahn1Mostafa M. H. Ellabaan2Morten O. A. Sommer3Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkNovo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkNovo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkNovo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.https://doi.org/10.1038/s41467-020-15080-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreas Porse Leonie J. Jahn Mostafa M. H. Ellabaan Morten O. A. Sommer |
spellingShingle |
Andreas Porse Leonie J. Jahn Mostafa M. H. Ellabaan Morten O. A. Sommer Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes Nature Communications |
author_facet |
Andreas Porse Leonie J. Jahn Mostafa M. H. Ellabaan Morten O. A. Sommer |
author_sort |
Andreas Porse |
title |
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes |
title_short |
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes |
title_full |
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes |
title_fullStr |
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes |
title_full_unstemmed |
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes |
title_sort |
dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-03-01 |
description |
The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution. |
url |
https://doi.org/10.1038/s41467-020-15080-8 |
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