Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs
Amyotrophic lateral sclerosis (ALS) is a complex and fatal neurodegenerative disease for which the causes of disease onset and progression remain unclear. Recent advances in human induced pluripotent stem cell (hiPSC)-based models permit the study of the genetic factors associated with ALS in patien...
Main Authors: | Madeline Halpern, Kristen J. Brennand, James Gregory |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-12-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611930230X |
Similar Items
-
Taking Cellular Heterogeneity Into Consideration When Modeling Astrocyte Involvement in Amyotrophic Lateral Sclerosis Using Human Induced Pluripotent Stem Cells
by: Stefano Stifani
Published: (2021-09-01) -
Formation and characterisation of neuromuscular junctions between hiPSC derived motoneurons and myotubes
by: M. Demestre, et al.
Published: (2015-09-01) -
Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs
by: Mengmeng Jin, et al.
Published: (2021-07-01) -
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
by: Claire E. Hall, et al.
Published: (2017-05-01) -
Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases
by: Jessica Lenzi, et al.
Published: (2016-07-01)