Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the β-subunit TMEM30A. Podocytes in the glomerulus form a filtration barrier to prevent the traversing of large cellula...

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Bibliographic Details
Main Authors: Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zhu
Format: Article
Language:English
Published: The Company of Biologists 2021-06-01
Series:Disease Models & Mechanisms
Subjects:
tmem30a
albuminuria
focal segmental glomerulosclerosis
glomerulosclerosis
Online Access:http://dmm.biologists.org/content/14/6/dmm048777

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