Adaptive Immunity to Hepatitis C Virus

The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This revie...

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Bibliographic Details
Main Authors: Françoise Stoll-Keller, Thomas f. Baumert, François Habersetzer, Samira Fafi-Kremer, Eric Robinet, Mirjam B. Zeisel
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:Viruses
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Online Access:http://www.mdpi.com/1999-4915/1/2/276/
Description
Summary:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on different aspects of the adaptive immune responses as determinants of the different outcomes of HCV infection, clearance or persistent infection, and outlines current concepts of HCV evasion strategies. Unravelling these important mechanisms of virus-host interaction will contribute to the development of novel strategies to prevent and control HCV infection.
ISSN:1999-4915