Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
Innate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22088-1 |
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doaj-60906122327e4f2e9beced154e87cbb72021-03-28T11:12:07ZengNature Publishing GroupNature Communications2041-17232021-03-0112111610.1038/s41467-021-22088-1Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signalingMichael C. Brown0Mubeen M. Mosaheb1Malte Mohme2Zachary P. McKay3Eda K. Holl4Jonathan P. Kastan5Yuanfan Yang6Georgia M. Beasley7E. Shelley Hwang8David M. Ashley9Darell D. Bigner10Smita K. Nair11Matthias Gromeier12Department of Neurosurgery, Duke University Medical SchoolDepartment of Molecular Genetics & Microbiology, Duke University Medical SchoolDepartment of Neurosurgery, University of Hamburg Medical CenterDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Surgery, Duke University Medical SchoolUniversity Program in Genetics & Genomics, Duke UniversityDepartment of Pathology, Duke University Medical SchoolDepartment of Surgery, Duke University Medical SchoolDepartment of Surgery, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Surgery, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolInnate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function.https://doi.org/10.1038/s41467-021-22088-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael C. Brown Mubeen M. Mosaheb Malte Mohme Zachary P. McKay Eda K. Holl Jonathan P. Kastan Yuanfan Yang Georgia M. Beasley E. Shelley Hwang David M. Ashley Darell D. Bigner Smita K. Nair Matthias Gromeier |
| spellingShingle |
Michael C. Brown Mubeen M. Mosaheb Malte Mohme Zachary P. McKay Eda K. Holl Jonathan P. Kastan Yuanfan Yang Georgia M. Beasley E. Shelley Hwang David M. Ashley Darell D. Bigner Smita K. Nair Matthias Gromeier Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling Nature Communications |
| author_facet |
Michael C. Brown Mubeen M. Mosaheb Malte Mohme Zachary P. McKay Eda K. Holl Jonathan P. Kastan Yuanfan Yang Georgia M. Beasley E. Shelley Hwang David M. Ashley Darell D. Bigner Smita K. Nair Matthias Gromeier |
| author_sort |
Michael C. Brown |
| title |
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling |
| title_short |
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling |
| title_full |
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling |
| title_fullStr |
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling |
| title_full_unstemmed |
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling |
| title_sort |
viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective tbk1-irf3 signaling |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
Innate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function. |
| url |
https://doi.org/10.1038/s41467-021-22088-1 |
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