Nanocarriers targeting senescent cells
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the pr...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2019-01-01
|
| Series: | Translational Medicine of Aging |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468501118300075 |
| Summary: | Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine. |
|---|---|
| ISSN: | 2468-5011 |