Nanocarriers targeting senescent cells
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the pr...
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Format: | Article |
Language: | English |
Published: |
KeAi Communications Co., Ltd.
2019-01-01
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Series: | Translational Medicine of Aging |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2468501118300075 |
Summary: | Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine. |
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ISSN: | 2468-5011 |