Nanocarriers targeting senescent cells

Nanocarriers targeting senescent cells

Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the pr...

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Main Author: Daniel Muñoz-Espín
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-01-01
Series:Translational Medicine of Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2468501118300075
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spelling doaj-60963e2fd06743e0b6f8c22ca23394442021-02-02T07:07:50ZengKeAi Communications Co., Ltd.Translational Medicine of Aging2468-50112019-01-01315Nanocarriers targeting senescent cellsDaniel Muñoz-Espín0CRUK Cambridge Centre Early Detection Programme, Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UKAgeing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine.http://www.sciencedirect.com/science/article/pii/S2468501118300075
collection DOAJ
language English
format Article
sources DOAJ
author Daniel Muñoz-Espín
spellingShingle Daniel Muñoz-Espín
Nanocarriers targeting senescent cells
Translational Medicine of Aging
author_facet Daniel Muñoz-Espín
author_sort Daniel Muñoz-Espín
title Nanocarriers targeting senescent cells
title_short Nanocarriers targeting senescent cells
title_full Nanocarriers targeting senescent cells
title_fullStr Nanocarriers targeting senescent cells
title_full_unstemmed Nanocarriers targeting senescent cells
title_sort nanocarriers targeting senescent cells
publisher KeAi Communications Co., Ltd.
series Translational Medicine of Aging
issn 2468-5011
publishDate 2019-01-01
description Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine.
url http://www.sciencedirect.com/science/article/pii/S2468501118300075
work_keys_str_mv AT danielmunozespin nanocarrierstargetingsenescentcells
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