Nanocarriers targeting senescent cells
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the pr...
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KeAi Communications Co., Ltd.
2019-01-01
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Series: | Translational Medicine of Aging |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2468501118300075 |
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doaj-60963e2fd06743e0b6f8c22ca23394442021-02-02T07:07:50ZengKeAi Communications Co., Ltd.Translational Medicine of Aging2468-50112019-01-01315Nanocarriers targeting senescent cellsDaniel Muñoz-Espín0CRUK Cambridge Centre Early Detection Programme, Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UKAgeing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine.http://www.sciencedirect.com/science/article/pii/S2468501118300075 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel Muñoz-Espín |
spellingShingle |
Daniel Muñoz-Espín Nanocarriers targeting senescent cells Translational Medicine of Aging |
author_facet |
Daniel Muñoz-Espín |
author_sort |
Daniel Muñoz-Espín |
title |
Nanocarriers targeting senescent cells |
title_short |
Nanocarriers targeting senescent cells |
title_full |
Nanocarriers targeting senescent cells |
title_fullStr |
Nanocarriers targeting senescent cells |
title_full_unstemmed |
Nanocarriers targeting senescent cells |
title_sort |
nanocarriers targeting senescent cells |
publisher |
KeAi Communications Co., Ltd. |
series |
Translational Medicine of Aging |
issn |
2468-5011 |
publishDate |
2019-01-01 |
description |
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations. It emerges that elimination of senescent cells ameliorates and even reverts the progression of age-related disorders, thereby extending healthspan and lifespan in preclinical mouse models. Development of delivery carriers specifically targeting senescent cells offers innovative therapeutic and diagnostic applications in translational medicine. |
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http://www.sciencedirect.com/science/article/pii/S2468501118300075 |
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AT danielmunozespin nanocarrierstargetingsenescentcells |
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