Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility
Abstract Behavioural flexibility is essential for everyday life. This involves shifting attention between different perspectives. Previous studies suggest that flexibility is mainly subserved by the dorsolateral prefrontal cortex (DLPFC). However, although rarely emphasized, the temporoparietal junc...
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doaj-6096e7a4e408446f8844ea6758fc400f2020-12-08T03:02:12ZengNature Publishing GroupScientific Reports2045-23222017-07-01711810.1038/s41598-017-06662-6Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural FlexibilityShisei Tei0Junya Fujino1Ryosaku Kawada2Kathryn F. Jankowski3Jukka-Pekka Kauppi4Wouter van den Bos5Nobuhito Abe6Genichi Sugihara7Jun Miyata8Toshiya Murai9Hidehiko Takahashi10Department of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychology, University of OregonDepartment of Mathematical Information Technology, University of JyväskyläCenter for Adaptive Rationality, Max Planck Institute for Human DevelopmentKokoro Research Center, Kyoto UniversityDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineAbstract Behavioural flexibility is essential for everyday life. This involves shifting attention between different perspectives. Previous studies suggest that flexibility is mainly subserved by the dorsolateral prefrontal cortex (DLPFC). However, although rarely emphasized, the temporoparietal junction (TPJ) is frequently recruited during flexible behaviour. A crucial question is whether TPJ plays a role in different types of flexibility, compared to its limited role in perceptual flexibility. We hypothesized that TPJ activity during diverse flexibility tasks plays a common role in stimulus-driven attention-shifting, thereby contributing to different types of flexibility, and thus the collaboration between DLPFC and TPJ might serve as a more appropriate mechanism than DLPFC alone. We used fMRI to measure DLPFC/TPJ activity recruited during moral flexibility, and examined its effect on other domains of flexibility (economic/perceptual). Here, we show the additional, yet crucial role of TPJ: a combined DLPFC/TPJ activity predicted flexibility, regardless of domain. Different types of flexibility might rely on more basic attention-shifting, which highlights the behavioural significance of alternatives.https://doi.org/10.1038/s41598-017-06662-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shisei Tei Junya Fujino Ryosaku Kawada Kathryn F. Jankowski Jukka-Pekka Kauppi Wouter van den Bos Nobuhito Abe Genichi Sugihara Jun Miyata Toshiya Murai Hidehiko Takahashi |
spellingShingle |
Shisei Tei Junya Fujino Ryosaku Kawada Kathryn F. Jankowski Jukka-Pekka Kauppi Wouter van den Bos Nobuhito Abe Genichi Sugihara Jun Miyata Toshiya Murai Hidehiko Takahashi Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility Scientific Reports |
author_facet |
Shisei Tei Junya Fujino Ryosaku Kawada Kathryn F. Jankowski Jukka-Pekka Kauppi Wouter van den Bos Nobuhito Abe Genichi Sugihara Jun Miyata Toshiya Murai Hidehiko Takahashi |
author_sort |
Shisei Tei |
title |
Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility |
title_short |
Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility |
title_full |
Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility |
title_fullStr |
Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility |
title_full_unstemmed |
Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility |
title_sort |
collaborative roles of temporoparietal junction and dorsolateral prefrontal cortex in different types of behavioural flexibility |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-07-01 |
description |
Abstract Behavioural flexibility is essential for everyday life. This involves shifting attention between different perspectives. Previous studies suggest that flexibility is mainly subserved by the dorsolateral prefrontal cortex (DLPFC). However, although rarely emphasized, the temporoparietal junction (TPJ) is frequently recruited during flexible behaviour. A crucial question is whether TPJ plays a role in different types of flexibility, compared to its limited role in perceptual flexibility. We hypothesized that TPJ activity during diverse flexibility tasks plays a common role in stimulus-driven attention-shifting, thereby contributing to different types of flexibility, and thus the collaboration between DLPFC and TPJ might serve as a more appropriate mechanism than DLPFC alone. We used fMRI to measure DLPFC/TPJ activity recruited during moral flexibility, and examined its effect on other domains of flexibility (economic/perceptual). Here, we show the additional, yet crucial role of TPJ: a combined DLPFC/TPJ activity predicted flexibility, regardless of domain. Different types of flexibility might rely on more basic attention-shifting, which highlights the behavioural significance of alternatives. |
url |
https://doi.org/10.1038/s41598-017-06662-6 |
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