Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study
Objectives: This study performed dosimetry studies and secondary cancer risk assessments on using electronic portal imaging device (EPID) and cone beam computed tomography (CBCT) as image guided tools for the early lung cancer patients treated with SBRT. Methods: The imaging doses from MV-EPID and k...
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Series: | Technology in Cancer Research & Treatment |
Online Access: | https://doi.org/10.1177/15330338211016472 |
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doaj-60a66a491b1e49a487f7511c7b91f7022021-06-29T22:04:01ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382021-05-012010.1177/15330338211016472Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico StudyYan-Hua Duan ME0Heng-Le Gu MS1Xiao-Hui Yang BS2Hua Chen ME3Hao Wang MS4Yan Shao MS5Xiao-Yang Li MD6Ai-Hui Feng MS7Yan-Chen Ying MS8Xiao-Long Fu PhD9Kui Ma10Tao Zhou11Zhi-Yong Xu PhD12 Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Engineering, Beijing Jingfang Technologies Co. Ltd, Beijing, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Clinical helpdesk, Varian Medical Systems, China Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, ChinaObjectives: This study performed dosimetry studies and secondary cancer risk assessments on using electronic portal imaging device (EPID) and cone beam computed tomography (CBCT) as image guided tools for the early lung cancer patients treated with SBRT. Methods: The imaging doses from MV-EPID and kV-CBCT of the Edge accelerator were retrospectively added to sixty-one SBRT treatment plans of early lung cancer patients. The MV-EPID imaging dose (6MV Photon beam) was calculated in Pinnacle TPS, and the kV-CBCT imaging dose was simulated and calculated by modeling of the kV energy beam in TPS using Pinnacle automatic modeling program. Three types of plans, namely Plan EPID , Plan CBCT and Plan origin , were generated with incorporating doses of EPID, CBCT and no imaging, respectively, for analysis. The effects of imaging doses on dose-volume-histogram (DVH) and plan quality were analyzed, and the excess absolute risk (EAR) of secondary cancer for ipsilateral lung was evaluated. Results: The regions that received less than 50 cGy were significantly impacted by the imaging doses, while the isodose lines greater than 1000 cGy were barely changed. The DVH values of ipsilateral lung increased the most in Plan EPID , followed by Plan CBCT . Compared to Plan origin on the average, the estimated EAR of ipsilateral lung in Plan EPID increased by 3.43%, while the corresponding EAR increase in Plan CBCT was much smaller (about 0.4%). Considering only the contribution of the imaging dose, the EAR values for the ipsilateral lung due to the MV-EPID dose in 5 years,10 years and 15 years were 1.49 cases, 2.09 cases and 2.88 cases per 10 4 PY respectively, and those due to the kV-CBCT dose were about 9 times lower, correspondingly. Conclusions: The imaging doses produced by MV-EPID and kV-CBCT had little effects on the target dose coverage. The secondary cancer risk caused by MV-EPID dose is more than 8.5 times that of kV-CBCT.https://doi.org/10.1177/15330338211016472 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan-Hua Duan ME Heng-Le Gu MS Xiao-Hui Yang BS Hua Chen ME Hao Wang MS Yan Shao MS Xiao-Yang Li MD Ai-Hui Feng MS Yan-Chen Ying MS Xiao-Long Fu PhD Kui Ma Tao Zhou Zhi-Yong Xu PhD |
spellingShingle |
Yan-Hua Duan ME Heng-Le Gu MS Xiao-Hui Yang BS Hua Chen ME Hao Wang MS Yan Shao MS Xiao-Yang Li MD Ai-Hui Feng MS Yan-Chen Ying MS Xiao-Long Fu PhD Kui Ma Tao Zhou Zhi-Yong Xu PhD Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study Technology in Cancer Research & Treatment |
author_facet |
Yan-Hua Duan ME Heng-Le Gu MS Xiao-Hui Yang BS Hua Chen ME Hao Wang MS Yan Shao MS Xiao-Yang Li MD Ai-Hui Feng MS Yan-Chen Ying MS Xiao-Long Fu PhD Kui Ma Tao Zhou Zhi-Yong Xu PhD |
author_sort |
Yan-Hua Duan ME |
title |
Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study |
title_short |
Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study |
title_full |
Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study |
title_fullStr |
Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study |
title_full_unstemmed |
Evaluation of IGRT-Induced Imaging Doses and Secondary Cancer Risk for SBRT Early Lung Cancer Patients In Silico Study |
title_sort |
evaluation of igrt-induced imaging doses and secondary cancer risk for sbrt early lung cancer patients in silico study |
publisher |
SAGE Publishing |
series |
Technology in Cancer Research & Treatment |
issn |
1533-0338 |
publishDate |
2021-05-01 |
description |
Objectives: This study performed dosimetry studies and secondary cancer risk assessments on using electronic portal imaging device (EPID) and cone beam computed tomography (CBCT) as image guided tools for the early lung cancer patients treated with SBRT. Methods: The imaging doses from MV-EPID and kV-CBCT of the Edge accelerator were retrospectively added to sixty-one SBRT treatment plans of early lung cancer patients. The MV-EPID imaging dose (6MV Photon beam) was calculated in Pinnacle TPS, and the kV-CBCT imaging dose was simulated and calculated by modeling of the kV energy beam in TPS using Pinnacle automatic modeling program. Three types of plans, namely Plan EPID , Plan CBCT and Plan origin , were generated with incorporating doses of EPID, CBCT and no imaging, respectively, for analysis. The effects of imaging doses on dose-volume-histogram (DVH) and plan quality were analyzed, and the excess absolute risk (EAR) of secondary cancer for ipsilateral lung was evaluated. Results: The regions that received less than 50 cGy were significantly impacted by the imaging doses, while the isodose lines greater than 1000 cGy were barely changed. The DVH values of ipsilateral lung increased the most in Plan EPID , followed by Plan CBCT . Compared to Plan origin on the average, the estimated EAR of ipsilateral lung in Plan EPID increased by 3.43%, while the corresponding EAR increase in Plan CBCT was much smaller (about 0.4%). Considering only the contribution of the imaging dose, the EAR values for the ipsilateral lung due to the MV-EPID dose in 5 years,10 years and 15 years were 1.49 cases, 2.09 cases and 2.88 cases per 10 4 PY respectively, and those due to the kV-CBCT dose were about 9 times lower, correspondingly. Conclusions: The imaging doses produced by MV-EPID and kV-CBCT had little effects on the target dose coverage. The secondary cancer risk caused by MV-EPID dose is more than 8.5 times that of kV-CBCT. |
url |
https://doi.org/10.1177/15330338211016472 |
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