Skull destruction from intracranial metastasis arising from pulmonary squamous cell carcinoma: a case report

• Main Authors: Kader Imran, Strong Michael, George Mathew
• Format: Article
• Language: English
• Published: BMC 2013-01-01
• Series: Journal of Medical Case Reports
• Subjects: Destruction of bone; Metastasis; Squamous cell carcinoma of the lung
• Online Access: http://www.jmedicalcasereports.com/content/7/1/28

<p>Abstract</p> <p>Introduction</p> <p>Squamous cell carcinoma of the lung represents 30% of all non-small cell lung carcinomas. It arises from dysplasia of squamous epithelium of the bronchi and is strongly associated with cigarette smoking. Squamous cell carcinoma of the lung is known to produce metastases in the brain parenchyma.</p> <p>Case presentation</p> <p>We present the case of an 80-year-old indigenous Australian man with an unusual presentation of metastatic carcinoma of the lung. The case demonstrated a squamous cell carcinoma of the lung with an intracranial metastatic lesion destroying the parietal bone and extending into the extracranial soft tissue. A visible deformity as a result of the metastasis was evident on physical examination and computed tomography demonstrated extensive bone destruction.</p> <p>Conclusion</p> <p>The authors were unable to find a case of this occurring from a squamous cell carcinoma of the lung anywhere in the world literature. The case report demonstrates an unusual disease presentation with a rare intracranial metastasis invading through the skull.</p>