Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study

Background Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period...

Full description

Bibliographic Details
Main Authors: Dong-Hyuk Cho, Hyung Joon Joo, Mi-Na Kim, Hee-Dong Kim, Do-Sun Lim, Seong-Mi Park
Format: Article
Language:English
Published: Korean Diabetes Association 2021-09-01
Series:Diabetes & Metabolism Journal
Subjects:
Online Access:http://www.e-dmj.org/upload/pdf/dmj-2020-0132.pdf
id doaj-60bcc38c7d5244359ad156107c723689
record_format Article
spelling doaj-60bcc38c7d5244359ad156107c7236892021-10-06T02:13:13ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872021-09-0145571972910.4093/dmj.2020.01322558Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up StudyDong-Hyuk Cho0Hyung Joon Joo1Mi-Na Kim2Hee-Dong Kim3Do-Sun Lim4Seong-Mi Park5 Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaBackground Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period in subjects with suspected MetS. Methods We studied 191 participants with suspected MetS at baseline and after 3 years. Anthropometric parameters, including waist circumference (WC), and metabolic parameters, including fasting blood glucose and lipid profile were measured. Conventional echocardiography with two-dimensional speckle tracking was performed. Results Mean age was 56.2±4.4 years, and there were 97 women (50.8%). Men had increased WC and triglycerides (TG) (WC 91.2±6.8 cm vs. 84.0±8.0 cm, P<0.001; TG 184.4±116.3 mg/dL vs. 128.2±53.6 mg/dL, P<0.001), and reduced global longitudinal strain (GLS) (–15.4%±2.1% vs. –17.1%±2.0%, P<0.001) compared to women. After 3.4 years, values of WC and TG did not change in men but increased in women (all P<0.05). The absolute value of left ventricular (LV) GLS did not change in men but was reduced in women (P=0.011). Change in TG was independently associated with worsening of LV GLS only in women (standardized β, –0.309; 95% confidence interval, –0.130 to –0.009; P=0.025). Conclusion In middle aged population, a vulnerable period for metabolic disturbance, cardiac remodeling tended to progress, which was prominent in women. Progression of adiposity and dyslipidemia after menopause may accelerate subclinical cardiac remodeling in middle-aged women. Lifestyle modification and medical interventions may help prevent further cardiac dysfunction in these subjects.http://www.e-dmj.org/upload/pdf/dmj-2020-0132.pdfmetabolic syndromelongitudinal studiessex characteristicsventricular dysfunction
collection DOAJ
language English
format Article
sources DOAJ
author Dong-Hyuk Cho
Hyung Joon Joo
Mi-Na Kim
Hee-Dong Kim
Do-Sun Lim
Seong-Mi Park
spellingShingle Dong-Hyuk Cho
Hyung Joon Joo
Mi-Na Kim
Hee-Dong Kim
Do-Sun Lim
Seong-Mi Park
Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
Diabetes & Metabolism Journal
metabolic syndrome
longitudinal studies
sex characteristics
ventricular dysfunction
author_facet Dong-Hyuk Cho
Hyung Joon Joo
Mi-Na Kim
Hee-Dong Kim
Do-Sun Lim
Seong-Mi Park
author_sort Dong-Hyuk Cho
title Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
title_short Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
title_full Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
title_fullStr Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
title_full_unstemmed Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
title_sort longitudinal change in myocardial function and clinical parameters in middle-aged subjects: a 3-year follow-up study
publisher Korean Diabetes Association
series Diabetes & Metabolism Journal
issn 2233-6079
2233-6087
publishDate 2021-09-01
description Background Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period in subjects with suspected MetS. Methods We studied 191 participants with suspected MetS at baseline and after 3 years. Anthropometric parameters, including waist circumference (WC), and metabolic parameters, including fasting blood glucose and lipid profile were measured. Conventional echocardiography with two-dimensional speckle tracking was performed. Results Mean age was 56.2±4.4 years, and there were 97 women (50.8%). Men had increased WC and triglycerides (TG) (WC 91.2±6.8 cm vs. 84.0±8.0 cm, P<0.001; TG 184.4±116.3 mg/dL vs. 128.2±53.6 mg/dL, P<0.001), and reduced global longitudinal strain (GLS) (–15.4%±2.1% vs. –17.1%±2.0%, P<0.001) compared to women. After 3.4 years, values of WC and TG did not change in men but increased in women (all P<0.05). The absolute value of left ventricular (LV) GLS did not change in men but was reduced in women (P=0.011). Change in TG was independently associated with worsening of LV GLS only in women (standardized β, –0.309; 95% confidence interval, –0.130 to –0.009; P=0.025). Conclusion In middle aged population, a vulnerable period for metabolic disturbance, cardiac remodeling tended to progress, which was prominent in women. Progression of adiposity and dyslipidemia after menopause may accelerate subclinical cardiac remodeling in middle-aged women. Lifestyle modification and medical interventions may help prevent further cardiac dysfunction in these subjects.
topic metabolic syndrome
longitudinal studies
sex characteristics
ventricular dysfunction
url http://www.e-dmj.org/upload/pdf/dmj-2020-0132.pdf
work_keys_str_mv AT donghyukcho longitudinalchangeinmyocardialfunctionandclinicalparametersinmiddleagedsubjectsa3yearfollowupstudy
AT hyungjoonjoo longitudinalchangeinmyocardialfunctionandclinicalparametersinmiddleagedsubjectsa3yearfollowupstudy
AT minakim longitudinalchangeinmyocardialfunctionandclinicalparametersinmiddleagedsubjectsa3yearfollowupstudy
AT heedongkim longitudinalchangeinmyocardialfunctionandclinicalparametersinmiddleagedsubjectsa3yearfollowupstudy
AT dosunlim longitudinalchangeinmyocardialfunctionandclinicalparametersinmiddleagedsubjectsa3yearfollowupstudy
AT seongmipark longitudinalchangeinmyocardialfunctionandclinicalparametersinmiddleagedsubjectsa3yearfollowupstudy
_version_ 1716841540532305920