Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study
Background Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period...
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Korean Diabetes Association
2021-09-01
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doaj-60bcc38c7d5244359ad156107c7236892021-10-06T02:13:13ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872021-09-0145571972910.4093/dmj.2020.01322558Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up StudyDong-Hyuk Cho0Hyung Joon Joo1Mi-Na Kim2Hee-Dong Kim3Do-Sun Lim4Seong-Mi Park5 Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaBackground Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period in subjects with suspected MetS. Methods We studied 191 participants with suspected MetS at baseline and after 3 years. Anthropometric parameters, including waist circumference (WC), and metabolic parameters, including fasting blood glucose and lipid profile were measured. Conventional echocardiography with two-dimensional speckle tracking was performed. Results Mean age was 56.2±4.4 years, and there were 97 women (50.8%). Men had increased WC and triglycerides (TG) (WC 91.2±6.8 cm vs. 84.0±8.0 cm, P<0.001; TG 184.4±116.3 mg/dL vs. 128.2±53.6 mg/dL, P<0.001), and reduced global longitudinal strain (GLS) (–15.4%±2.1% vs. –17.1%±2.0%, P<0.001) compared to women. After 3.4 years, values of WC and TG did not change in men but increased in women (all P<0.05). The absolute value of left ventricular (LV) GLS did not change in men but was reduced in women (P=0.011). Change in TG was independently associated with worsening of LV GLS only in women (standardized β, –0.309; 95% confidence interval, –0.130 to –0.009; P=0.025). Conclusion In middle aged population, a vulnerable period for metabolic disturbance, cardiac remodeling tended to progress, which was prominent in women. Progression of adiposity and dyslipidemia after menopause may accelerate subclinical cardiac remodeling in middle-aged women. Lifestyle modification and medical interventions may help prevent further cardiac dysfunction in these subjects.http://www.e-dmj.org/upload/pdf/dmj-2020-0132.pdfmetabolic syndromelongitudinal studiessex characteristicsventricular dysfunction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong-Hyuk Cho Hyung Joon Joo Mi-Na Kim Hee-Dong Kim Do-Sun Lim Seong-Mi Park |
spellingShingle |
Dong-Hyuk Cho Hyung Joon Joo Mi-Na Kim Hee-Dong Kim Do-Sun Lim Seong-Mi Park Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study Diabetes & Metabolism Journal metabolic syndrome longitudinal studies sex characteristics ventricular dysfunction |
author_facet |
Dong-Hyuk Cho Hyung Joon Joo Mi-Na Kim Hee-Dong Kim Do-Sun Lim Seong-Mi Park |
author_sort |
Dong-Hyuk Cho |
title |
Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study |
title_short |
Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study |
title_full |
Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study |
title_fullStr |
Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study |
title_full_unstemmed |
Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study |
title_sort |
longitudinal change in myocardial function and clinical parameters in middle-aged subjects: a 3-year follow-up study |
publisher |
Korean Diabetes Association |
series |
Diabetes & Metabolism Journal |
issn |
2233-6079 2233-6087 |
publishDate |
2021-09-01 |
description |
Background Metabolic syndrome (MetS) is closely associated with the aging process. However, changes in metabolic conditions and cardiac function that occur in middle aged population remain unclear. We evaluated longitudinal changes in metabolic parameters and cardiac function during a 3-year period in subjects with suspected MetS. Methods We studied 191 participants with suspected MetS at baseline and after 3 years. Anthropometric parameters, including waist circumference (WC), and metabolic parameters, including fasting blood glucose and lipid profile were measured. Conventional echocardiography with two-dimensional speckle tracking was performed. Results Mean age was 56.2±4.4 years, and there were 97 women (50.8%). Men had increased WC and triglycerides (TG) (WC 91.2±6.8 cm vs. 84.0±8.0 cm, P<0.001; TG 184.4±116.3 mg/dL vs. 128.2±53.6 mg/dL, P<0.001), and reduced global longitudinal strain (GLS) (–15.4%±2.1% vs. –17.1%±2.0%, P<0.001) compared to women. After 3.4 years, values of WC and TG did not change in men but increased in women (all P<0.05). The absolute value of left ventricular (LV) GLS did not change in men but was reduced in women (P=0.011). Change in TG was independently associated with worsening of LV GLS only in women (standardized β, –0.309; 95% confidence interval, –0.130 to –0.009; P=0.025). Conclusion In middle aged population, a vulnerable period for metabolic disturbance, cardiac remodeling tended to progress, which was prominent in women. Progression of adiposity and dyslipidemia after menopause may accelerate subclinical cardiac remodeling in middle-aged women. Lifestyle modification and medical interventions may help prevent further cardiac dysfunction in these subjects. |
topic |
metabolic syndrome longitudinal studies sex characteristics ventricular dysfunction |
url |
http://www.e-dmj.org/upload/pdf/dmj-2020-0132.pdf |
work_keys_str_mv |
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