A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation andÂ Promotes Ischemia Reperfusion InjuryÂ inÂ the Heart

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation andÂ Promotes Ischemia Reperfusion InjuryÂ inÂ the Heart

Summary: Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte; its inhibitory activity to sarcolemma-endoplasmic reticulum calcium ATPase is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in the failing heart. The current study pro...

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Bibliographic Details
Main Authors:	Toru Akaike, MD, PhD, Na Du, MD, PhD, Gang Lu, PhD, Susumu Minamisawa, MD, PhD, Yibin Wang, PhD, Hongmei Ruan, MD, PhD
Format:	Article
Language:	English
Published:	Elsevier 2017-04-01
Series:	JACC: Basic to Translational Science
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452302X17300505

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