A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart
Summary: Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte; its inhibitory activity to sarcolemma-endoplasmic reticulum calcium ATPase is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in the failing heart. The current study pro...
Main Authors: | Toru Akaike, MD, PhD, Na Du, MD, PhD, Gang Lu, PhD, Susumu Minamisawa, MD, PhD, Yibin Wang, PhD, Hongmei Ruan, MD, PhD |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-04-01
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Series: | JACC: Basic to Translational Science |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X17300505 |
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