Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD...
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Online Access: | http://dx.doi.org/10.1080/20008198.2020.1857955 |
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doaj-60caf1e6867c46acaebc1437876c14e52021-06-25T11:10:04ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662021-01-0112110.1080/20008198.2020.18579551857955Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performanceNeus Salvat-Pujol0Javier Labad1Mikel Urretavizcaya2Aida de Arriba-Arnau3Cinto Segalàs4Eva Real5Alex Ferrer6José M. Crespo7Susana Jiménez-Murcia8Carles Soriano-Mas9José M. Menchón10Virginia Soria11Neurosciences Group - Psychiatry and Mental HealthCarlos III Health InstituteNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthNeurosciences Group - Psychiatry and Mental HealthBackground: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects.http://dx.doi.org/10.1080/20008198.2020.1857955childhood abusechildhood neglectcortisolhpa axisdexamethasone suppression testcognitionmemorymajor depression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neus Salvat-Pujol Javier Labad Mikel Urretavizcaya Aida de Arriba-Arnau Cinto Segalàs Eva Real Alex Ferrer José M. Crespo Susana Jiménez-Murcia Carles Soriano-Mas José M. Menchón Virginia Soria |
spellingShingle |
Neus Salvat-Pujol Javier Labad Mikel Urretavizcaya Aida de Arriba-Arnau Cinto Segalàs Eva Real Alex Ferrer José M. Crespo Susana Jiménez-Murcia Carles Soriano-Mas José M. Menchón Virginia Soria Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance European Journal of Psychotraumatology childhood abuse childhood neglect cortisol hpa axis dexamethasone suppression test cognition memory major depression |
author_facet |
Neus Salvat-Pujol Javier Labad Mikel Urretavizcaya Aida de Arriba-Arnau Cinto Segalàs Eva Real Alex Ferrer José M. Crespo Susana Jiménez-Murcia Carles Soriano-Mas José M. Menchón Virginia Soria |
author_sort |
Neus Salvat-Pujol |
title |
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
title_short |
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
title_full |
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
title_fullStr |
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
title_full_unstemmed |
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
title_sort |
childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
publisher |
Taylor & Francis Group |
series |
European Journal of Psychotraumatology |
issn |
2000-8066 |
publishDate |
2021-01-01 |
description |
Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects. |
topic |
childhood abuse childhood neglect cortisol hpa axis dexamethasone suppression test cognition memory major depression |
url |
http://dx.doi.org/10.1080/20008198.2020.1857955 |
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