Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients
Purpose: Bariatric surgery is an efficient procedure for the remission of type 2 diabetes (T2DM) from morbid obesity. However, in Asian countries, the mean body mass index (BMI) of T2DM patients is about 25 kg/m2. Various data on patients undergoing gastric bypass surgery suggest that the control of...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-07-01
|
Series: | Asian Journal of Surgery |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958413000985 |
id |
doaj-60da0e1cf5b74bb9b9c9f50926df4d74 |
---|---|
record_format |
Article |
spelling |
doaj-60da0e1cf5b74bb9b9c9f50926df4d742020-11-24T23:21:44ZengElsevierAsian Journal of Surgery1015-95842014-07-0137313013710.1016/j.asjsur.2013.09.008Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patientsMyung Jin Kim0Hyeong Kyu Park1Dong Won Byun2Kyo Il Suh3Kyung Yul Hur4Department of Surgery, Soonchunhyang University College of Medicine, Seoul, South KoreaDepartment of Endocrinology, Soonchunhyang University College of Medicine, Seoul, South KoreaDepartment of Endocrinology, Soonchunhyang University College of Medicine, Seoul, South KoreaDepartment of Endocrinology, Soonchunhyang University College of Medicine, Seoul, South KoreaDepartment of Surgery, Soonchunhyang University College of Medicine, Seoul, South KoreaPurpose: Bariatric surgery is an efficient procedure for the remission of type 2 diabetes (T2DM) from morbid obesity. However, in Asian countries, the mean body mass index (BMI) of T2DM patients is about 25 kg/m2. Various data on patients undergoing gastric bypass surgery suggest that the control of T2DM after surgery occurs rapidly. We hypothesized that even in nonobese patients with T2DM, the levels of incretin and insulin changed along with the improvement of T2DM as a consequence of the gastric bypass. Materials and methods: From March to December 2011, 12 nonobese patients (mean BMI; 26.2 kg/m2) with poorly-controlled [mean glycated hemoglobin (HbA1C); 9.5%] diabetes underwent gastric bypass surgery. Values related to diabetes, including incretin [gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1)] levels were measured before and 1 month after surgery. All values were measured in response to a 75 g oral glucose tolerance test (OGTT). Results: On average, the BMI decreased by 2.1 ± 0.7 kg/m2. Mean HbA1C level decreased by 1.6 ± 2%. Oral glucose-stimulated insulin levels increased and GLP-1 levels also increased significantly. Oral glucose-stimulated GIP levels decreased sharply. Conclusion: Soon after gastric bypass in nonobese T2DM patients, control of T2DM is achieved. The incretin release after oral glucose is improved. This could be a consequence of changes of the enteroinsular axis, particularly in the incretins.http://www.sciencedirect.com/science/article/pii/S1015958413000985gastric bypassincretinmetabolic surgerytype 2 diabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Myung Jin Kim Hyeong Kyu Park Dong Won Byun Kyo Il Suh Kyung Yul Hur |
spellingShingle |
Myung Jin Kim Hyeong Kyu Park Dong Won Byun Kyo Il Suh Kyung Yul Hur Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients Asian Journal of Surgery gastric bypass incretin metabolic surgery type 2 diabetes mellitus |
author_facet |
Myung Jin Kim Hyeong Kyu Park Dong Won Byun Kyo Il Suh Kyung Yul Hur |
author_sort |
Myung Jin Kim |
title |
Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients |
title_short |
Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients |
title_full |
Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients |
title_fullStr |
Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients |
title_full_unstemmed |
Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients |
title_sort |
incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients |
publisher |
Elsevier |
series |
Asian Journal of Surgery |
issn |
1015-9584 |
publishDate |
2014-07-01 |
description |
Purpose: Bariatric surgery is an efficient procedure for the remission of type 2 diabetes (T2DM) from morbid obesity. However, in Asian countries, the mean body mass index (BMI) of T2DM patients is about 25 kg/m2. Various data on patients undergoing gastric bypass surgery suggest that the control of T2DM after surgery occurs rapidly. We hypothesized that even in nonobese patients with T2DM, the levels of incretin and insulin changed along with the improvement of T2DM as a consequence of the gastric bypass.
Materials and methods: From March to December 2011, 12 nonobese patients (mean BMI; 26.2 kg/m2) with poorly-controlled [mean glycated hemoglobin (HbA1C); 9.5%] diabetes underwent gastric bypass surgery. Values related to diabetes, including incretin [gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1)] levels were measured before and 1 month after surgery. All values were measured in response to a 75 g oral glucose tolerance test (OGTT).
Results: On average, the BMI decreased by 2.1 ± 0.7 kg/m2. Mean HbA1C level decreased by 1.6 ± 2%. Oral glucose-stimulated insulin levels increased and GLP-1 levels also increased significantly. Oral glucose-stimulated GIP levels decreased sharply.
Conclusion: Soon after gastric bypass in nonobese T2DM patients, control of T2DM is achieved. The incretin release after oral glucose is improved. This could be a consequence of changes of the enteroinsular axis, particularly in the incretins. |
topic |
gastric bypass incretin metabolic surgery type 2 diabetes mellitus |
url |
http://www.sciencedirect.com/science/article/pii/S1015958413000985 |
work_keys_str_mv |
AT myungjinkim incretinlevels1monthafterlaparoscopicsingleanastomosisgastricbypasssurgeryinnonmorbidobesetype2diabetespatients AT hyeongkyupark incretinlevels1monthafterlaparoscopicsingleanastomosisgastricbypasssurgeryinnonmorbidobesetype2diabetespatients AT dongwonbyun incretinlevels1monthafterlaparoscopicsingleanastomosisgastricbypasssurgeryinnonmorbidobesetype2diabetespatients AT kyoilsuh incretinlevels1monthafterlaparoscopicsingleanastomosisgastricbypasssurgeryinnonmorbidobesetype2diabetespatients AT kyungyulhur incretinlevels1monthafterlaparoscopicsingleanastomosisgastricbypasssurgeryinnonmorbidobesetype2diabetespatients |
_version_ |
1725570188949061632 |