Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation

Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation

Cooling reduces the ischemia/reperfusion (I/R) injury seen in sudden cardiac arrest (SCA) by decreasing the burst of reactive oxygen species (ROS). Its cardioprotection is diminished when delay in reaching the target temperature occurs. Baicalein, a flavonoid derived from the root of Scutellaria bai...

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Bibliographic Details
Main Authors: Zuohui Shao, Sy-Jou Chen, Xiangdong Zhu, Chunpei Lee, Hsien-Hao Huang, Angelo Meliton, Changqing Li, Terry L. Vanden Hoek, Jing Li
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
intraischemic cooling
delayed cooling
baicalein
ischemia/reperfusion
reactive oxygen species (ROS)
cardiomyocyte
Akt
cell death
contractility
Online Access:http://www.mdpi.com/1422-0067/19/4/973

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http://www.mdpi.com/1422-0067/19/4/973

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