IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes

IgLON5-associated encephalitis is a syndrome with different clinical presentations consisting of sleep dysfunction, bulbar dysfunction, chorea, and progressive supranuclear palsy-like symptoms whereas dysautonomy and cognitive decline usually appear in later stages of the disease. We report a case o...

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Main Authors:	Massimiliano Montagna, Rizvana Amir, Ilse De Volder, Martin Lammens, Jef Huyskens, Barbara Willekens
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Neurology
Subjects:	brain inflammation IgLON5 autoimmune encephalitis rapidly evolving dementia akathisia dyskinesia
Online Access:	http://journal.frontiersin.org/article/10.3389/fneur.2018.00329/full

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spelling	doaj-61003c7bf9204d2884b5ab82d33febaa2020-11-25T01:12:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-05-01910.3389/fneur.2018.00329367467IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid ChangesMassimiliano Montagna0Massimiliano Montagna1Rizvana Amir2Ilse De Volder3Ilse De Volder4Martin Lammens5Jef Huyskens6Barbara Willekens7Barbara Willekens8Department of Neurology, Antwerp University Hospital, Antwerp, BelgiumMaster After Master in Medicine, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Neurology, Sint Maarten General Hospital, Mechelen, BelgiumDepartment of Neurology, Antwerp University Hospital, Antwerp, BelgiumMultidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Antwerp, BelgiumDepartment of Pathology, Antwerp University Hospital, University of Antwerp, Antwerp, BelgiumDepartment of Radiology, Antwerp University Hospital, Antwerp, BelgiumDepartment of Neurology, Antwerp University Hospital, Antwerp, BelgiumLaboratory of Experimental Hematology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumIgLON5-associated encephalitis is a syndrome with different clinical presentations consisting of sleep dysfunction, bulbar dysfunction, chorea, and progressive supranuclear palsy-like symptoms whereas dysautonomy and cognitive decline usually appear in later stages of the disease. We report a case of a patient with IgLON5-associated encephalitis presenting with rapidly progressive cognitive decline and atypical inflammatory lesions on brain magnetic resonance imaging, oligoclonal bands on cerebrospinal fluid, anti-IgLON5 antibodies exclusively of the IgG1 class, and a fierce inflammatory reaction on brain biopsy, who responded favorably to immunotherapy.http://journal.frontiersin.org/article/10.3389/fneur.2018.00329/fullbrain inflammationIgLON5autoimmune encephalitisrapidly evolving dementiaakathisiadyskinesia
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Massimiliano Montagna Massimiliano Montagna Rizvana Amir Ilse De Volder Ilse De Volder Martin Lammens Jef Huyskens Barbara Willekens Barbara Willekens
spellingShingle	Massimiliano Montagna Massimiliano Montagna Rizvana Amir Ilse De Volder Ilse De Volder Martin Lammens Jef Huyskens Barbara Willekens Barbara Willekens IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes Frontiers in Neurology brain inflammation IgLON5 autoimmune encephalitis rapidly evolving dementia akathisia dyskinesia
author_facet	Massimiliano Montagna Massimiliano Montagna Rizvana Amir Ilse De Volder Ilse De Volder Martin Lammens Jef Huyskens Barbara Willekens Barbara Willekens
author_sort	Massimiliano Montagna
title	IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes
title_short	IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes
title_full	IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes
title_fullStr	IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes
title_full_unstemmed	IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes
title_sort	iglon5-associated encephalitis with atypical brain magnetic resonance imaging and cerebrospinal fluid changes
publisher	Frontiers Media S.A.
series	Frontiers in Neurology
issn	1664-2295
publishDate	2018-05-01
description	IgLON5-associated encephalitis is a syndrome with different clinical presentations consisting of sleep dysfunction, bulbar dysfunction, chorea, and progressive supranuclear palsy-like symptoms whereas dysautonomy and cognitive decline usually appear in later stages of the disease. We report a case of a patient with IgLON5-associated encephalitis presenting with rapidly progressive cognitive decline and atypical inflammatory lesions on brain magnetic resonance imaging, oligoclonal bands on cerebrospinal fluid, anti-IgLON5 antibodies exclusively of the IgG1 class, and a fierce inflammatory reaction on brain biopsy, who responded favorably to immunotherapy.
topic	brain inflammation IgLON5 autoimmune encephalitis rapidly evolving dementia akathisia dyskinesia
url	http://journal.frontiersin.org/article/10.3389/fneur.2018.00329/full
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IgLON5-Associated Encephalitis With Atypical Brain Magnetic Resonance Imaging and Cerebrospinal Fluid Changes

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