Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos

• Main Authors: Andréa Janaina M. Nogueira, Marco Edilson F. de Lima, João Batista N. DaCosta, Eliomara Sousa Sobral Alves, Danielle Oliveira dos Anjos, Marcos André Vannier-Santos, Adriana Lanfredi-Rangel
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2011-01-01
• Series: Química Nova
• Subjects: leishmaniases; Chagas disease; dialkylphosphorylhydrazones
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800013&lng=en&tlng=en
• ISSN: 1678-7064

A new series of dialkylphosphorylhydrazones was synthesized through the condensation of aromatic aldehydes with different phosphorylhydrazines. All synthesized compounds were characterized by IR, ¹H-NMR, 13C-NMR and 31P-NMR spectroscopies. The in vitro investigation of the activity of these compounds against Leishmania amazonensis promastigotes and epimastigotes of T. cruzi, showed an efficient inhibition of proliferation, at non toxic concentrations to mammalian cells. The results have shown some derivatives as potential antiparasitic agents against trypanosomatids.