Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials
Shaodong Hong,1,* Wenfeng Fang,1,* Wenhua Liang,1,* Yue Yan,1 Ting Zhou,1 Tao Qin,1 Xuan Wu,1 Yuxiang Ma,1 Yuanyuan Zhao,1 Yunpeng Yang,1 Zhihuang Hu,1 Cong Xue,1 Xue Hou,1 Yue Chen,2 Yan Huang,1 Hongyun Zhao,1 Li Zhang1 1State Key Laboratory of Oncology in South China, Collaborative Innovation Cen...
Main Authors: | , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2014-10-01
|
Series: | OncoTargets and Therapy |
Online Access: | http://www.dovepress.com/risk-of-treatment-related-deaths-with-vascular-endothelial-growth-fact-peer-reviewed-article-OTT |
id |
doaj-6112393529c7405abd7e86e7f5b3d266 |
---|---|
record_format |
Article |
spelling |
doaj-6112393529c7405abd7e86e7f5b3d2662020-11-25T01:09:44ZengDove Medical PressOncoTargets and Therapy1178-69302014-10-012014default1851186718668Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trialsHong SDFang WFLiang WHYan YZhou TQin TWu XMa YXZhao YYYang YPHu ZHXue CHou XChen YHuang YZhao HYZhang L Shaodong Hong,1,* Wenfeng Fang,1,* Wenhua Liang,1,* Yue Yan,1 Ting Zhou,1 Tao Qin,1 Xuan Wu,1 Yuxiang Ma,1 Yuanyuan Zhao,1 Yunpeng Yang,1 Zhihuang Hu,1 Cong Xue,1 Xue Hou,1 Yue Chen,2 Yan Huang,1 Hongyun Zhao,1 Li Zhang1 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; 2Medical School, University of South China, Hengyang, Hunan, People's Republic of China *These authors contributed equally to this work Background: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have widely been used in advanced cancer. However, these drugs may also lead to serious adverse events. The present meta-analysis aimed to determine the overall incidence and risk of deaths due to VEGFR-TKIs with more detailed subgroup analysis. Materials and methods: PubMed, Web of Science, and Cochrane databases were searched for randomized controlled trials (RCTs) that compared VEGFR-TKIs with non-VEGFR-TKIs in the treatment of solid cancer. Pooled incidence, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects models based on the heterogeneity of included trials. Results: A total of 14,139 participants from 41 RCTs were enrolled. The pooled incidence of death due to VEGFR-TKIs was 1.9% (95% CI: 1.6%–2.3%) with an OR of 1.85 (95% CI: 1.33–2.58; P<0.01) when compared with control groups. On subgroup analysis, significantly increased risk of death was found in patients with nonsmall-cell lung cancer (OR: 2.37; 95% CI: 1.19–4.73; P=0.01) and colorectal cancer (OR: 2.84; 95% CI: 1.02–7.96; P=0.05). Among different VEGFR-TKIs, sorafenib and sunitinib had significant risk of death when compared with control arms, respectively. VEGFR-TKIs in combination with other antineoplastic agents, but not VEGFR-TKI monotherapy, significantly increased the risk of treatment-related deaths. No heterogeneity was noted across all the prespecified subgroups regarding ORs. Conclusion: The present work pointed out a significantly increased risk of death due to VEGFR-TKIs. Close monitoring should be emphasized in patients receiving these drugs. Keywords: cancer, tyrosine kinase inhibitors, treatment-related death, meta-analysishttp://www.dovepress.com/risk-of-treatment-related-deaths-with-vascular-endothelial-growth-fact-peer-reviewed-article-OTT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong SD Fang WF Liang WH Yan Y Zhou T Qin T Wu X Ma YX Zhao YY Yang YP Hu ZH Xue C Hou X Chen Y Huang Y Zhao HY Zhang L |
spellingShingle |
Hong SD Fang WF Liang WH Yan Y Zhou T Qin T Wu X Ma YX Zhao YY Yang YP Hu ZH Xue C Hou X Chen Y Huang Y Zhao HY Zhang L Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials OncoTargets and Therapy |
author_facet |
Hong SD Fang WF Liang WH Yan Y Zhou T Qin T Wu X Ma YX Zhao YY Yang YP Hu ZH Xue C Hou X Chen Y Huang Y Zhao HY Zhang L |
author_sort |
Hong SD |
title |
Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials |
title_short |
Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials |
title_full |
Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials |
title_fullStr |
Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials |
title_full_unstemmed |
Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials |
title_sort |
risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2014-10-01 |
description |
Shaodong Hong,1,* Wenfeng Fang,1,* Wenhua Liang,1,* Yue Yan,1 Ting Zhou,1 Tao Qin,1 Xuan Wu,1 Yuxiang Ma,1 Yuanyuan Zhao,1 Yunpeng Yang,1 Zhihuang Hu,1 Cong Xue,1 Xue Hou,1 Yue Chen,2 Yan Huang,1 Hongyun Zhao,1 Li Zhang1 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; 2Medical School, University of South China, Hengyang, Hunan, People's Republic of China *These authors contributed equally to this work Background: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have widely been used in advanced cancer. However, these drugs may also lead to serious adverse events. The present meta-analysis aimed to determine the overall incidence and risk of deaths due to VEGFR-TKIs with more detailed subgroup analysis. Materials and methods: PubMed, Web of Science, and Cochrane databases were searched for randomized controlled trials (RCTs) that compared VEGFR-TKIs with non-VEGFR-TKIs in the treatment of solid cancer. Pooled incidence, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects models based on the heterogeneity of included trials. Results: A total of 14,139 participants from 41 RCTs were enrolled. The pooled incidence of death due to VEGFR-TKIs was 1.9% (95% CI: 1.6%–2.3%) with an OR of 1.85 (95% CI: 1.33–2.58; P<0.01) when compared with control groups. On subgroup analysis, significantly increased risk of death was found in patients with nonsmall-cell lung cancer (OR: 2.37; 95% CI: 1.19–4.73; P=0.01) and colorectal cancer (OR: 2.84; 95% CI: 1.02–7.96; P=0.05). Among different VEGFR-TKIs, sorafenib and sunitinib had significant risk of death when compared with control arms, respectively. VEGFR-TKIs in combination with other antineoplastic agents, but not VEGFR-TKI monotherapy, significantly increased the risk of treatment-related deaths. No heterogeneity was noted across all the prespecified subgroups regarding ORs. Conclusion: The present work pointed out a significantly increased risk of death due to VEGFR-TKIs. Close monitoring should be emphasized in patients receiving these drugs. Keywords: cancer, tyrosine kinase inhibitors, treatment-related death, meta-analysis |
url |
http://www.dovepress.com/risk-of-treatment-related-deaths-with-vascular-endothelial-growth-fact-peer-reviewed-article-OTT |
work_keys_str_mv |
AT hongsd riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT fangwf riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT liangwh riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT yany riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT zhout riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT qint riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT wux riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT mayx riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT zhaoyy riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT yangyp riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT huzh riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT xuec riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT houx riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT cheny riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT huangy riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT zhaohy riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials AT zhangl riskoftreatmentrelateddeathswithvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsametaanalysisof41randomizedcontrolledtrials |
_version_ |
1725176964895997952 |