Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-in...

Full description

Bibliographic Details
Main Authors: John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, Arup K. Chakraborty
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11660
id doaj-6124de3f685042c7ac6137c260b38667
record_format Article
spelling doaj-6124de3f685042c7ac6137c260b386672021-05-11T10:52:24ZengNature Publishing GroupNature Communications2041-17232016-05-017111010.1038/ncomms11660Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictableJohn P. Barton0Nilu Goonetilleke1Thomas C. Butler2Bruce D. Walker3Andrew J. McMichael4Arup K. Chakraborty5Ragon Institute of MGH, MIT and HarvardDepartment of Microbiology, Immunology and Medicine, University of North CarolinaDepartment of Chemical Engineering, Massachusetts Institute of TechnologyRagon Institute of MGH, MIT and HarvardNuffield Department of Medicine, University of OxfordRagon Institute of MGH, MIT and HarvardHIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons.https://doi.org/10.1038/ncomms11660
collection DOAJ
language English
format Article
sources DOAJ
author John P. Barton
Nilu Goonetilleke
Thomas C. Butler
Bruce D. Walker
Andrew J. McMichael
Arup K. Chakraborty
spellingShingle John P. Barton
Nilu Goonetilleke
Thomas C. Butler
Bruce D. Walker
Andrew J. McMichael
Arup K. Chakraborty
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
Nature Communications
author_facet John P. Barton
Nilu Goonetilleke
Thomas C. Butler
Bruce D. Walker
Andrew J. McMichael
Arup K. Chakraborty
author_sort John P. Barton
title Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_short Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_full Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_fullStr Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_full_unstemmed Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_sort relative rate and location of intra-host hiv evolution to evade cellular immunity are predictable
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-05-01
description HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons.
url https://doi.org/10.1038/ncomms11660
work_keys_str_mv AT johnpbarton relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable
AT nilugoonetilleke relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable
AT thomascbutler relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable
AT brucedwalker relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable
AT andrewjmcmichael relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable
AT arupkchakraborty relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable
_version_ 1721447400628813824

Similar Items