Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells
Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in the human lung. In this study, we demon...
Main Authors: | Harpa Karadottir, Nikhil Nitin Kulkarni, Thorarinn Gudjonsson, Sigurbergur Karason, Gudmundur Hrafn Gudmundsson |
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Format: | Article |
Language: | English |
Published: |
PeerJ Inc.
2015-12-01
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Series: | PeerJ |
Subjects: | |
Online Access: | https://peerj.com/articles/1483.pdf |
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