Hepatoprotective Efficacy of Pyrimidine Derivatives in Acute Dichloroethane Intoxication

• Main Authors: D. V. Srubilin, V. A. Myshkin, M. A. Isakova, D. A. Yenikeyev, A. I. Savlukov
• Format: Article
• Language: Russian
• Published: Russian Academy of Medical Sciences 2006-12-01
• Series: Obŝaâ Reanimatologiâ
• Subjects: lipid peroxidation; antioxidants; pyrimidine derivatives; 1,2-dichlorothane; hepatoprotectors; toxic hepatitis
• Online Access: https://www.reanimatology.com/rmt/article/view/1375

The paper presents the results of a study of the antioxidative and hematoprotective properties of pyrimidine derivatives: 1,3,6-trimethyl-5-hydroxyuracil and 3,6-dimethyl-5-hydrpxyuracil versus the synthetic antioxidant tonarol, а-tocopherol acetate, and the antihypoxant ethomerzole. In model systems of varying complexity, the antiradical activity of pyrimidines and their effects on spontaneous, ascorbate- and NADPH-dependent lipid peroxidation processes, as well as their protective activity were studied in different types of hypoxia. The pyrimidine derivatives were found to have the high antioxidative activity comparable with that of ionol. 1,3,6-trimethyl-5-hydroxyuracil has antihypoxic activity. Dichloroethane induced acute toxic hepatitis whose major manifestations were cytolysis, cholestasis, lipid metabolic disturbances, and an activated lipid peroxidation response. 1,3,6-trimethyl-5-hydroxyuracil limits the cytotoxic and cholestatic activity of dichloroethane, stabilizes lipid metabolism and lipid peroxidation reactions, and increases life span and survival in rats.