NADPH Oxidase-Mediated Activation of Neutral Sphingomyelinase Is Responsible for Diesel Particulate Extract-Induced Keratinocyte Apoptosis

NADPH Oxidase-Mediated Activation of Neutral Sphingomyelinase Is Responsible for Diesel Particulate Extract-Induced Keratinocyte Apoptosis

Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular fun...

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Bibliographic Details
Main Authors: Hyun-Seok Lee, Hye Yoon Park, Sung Pil Kwon, Bogyeong Kim, Yerin Lee, Seongeun Kim, Kyong-Oh Shin, Kyungho Park
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
diesel particulate extract
keratinocyte apoptosis
nadph oxidase
ceramide
neutral sphingomyelinase
Online Access:https://www.mdpi.com/1422-0067/21/3/1001

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