Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease

Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeuti...

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Main Authors: Antonela Lelas, Hildegard Theresia Greinix, Daniel Wolff, Günther Eissner, Steven Zivko Pavletic, Drazen Pulanic
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/full
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spelling doaj-6150901f3dcc4f22bfe0156292d4a2832021-04-30T04:49:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.676756676756Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host DiseaseAntonela Lelas0Hildegard Theresia Greinix1Daniel Wolff2Günther Eissner3Steven Zivko Pavletic4Drazen Pulanic5Drazen Pulanic6Division of Hematology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, CroatiaDivision of Hematology, Medical University of Graz, Graz, AustriaDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, GermanySystems Biology Ireland, School of Medicine, Conway Institute, University College Dublin, Dublin, IrelandCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesDivision of Hematology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaChronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/fullendothelial dysfunctioninflammationfactor VIIIVon Willeband factorchronic graft-versus-host disease (cGvHD)allogeneic hematopoietic stem cell transplantation
collection DOAJ
language English
format Article
sources DOAJ
author Antonela Lelas
Hildegard Theresia Greinix
Daniel Wolff
Günther Eissner
Steven Zivko Pavletic
Drazen Pulanic
Drazen Pulanic
spellingShingle Antonela Lelas
Hildegard Theresia Greinix
Daniel Wolff
Günther Eissner
Steven Zivko Pavletic
Drazen Pulanic
Drazen Pulanic
Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
Frontiers in Immunology
endothelial dysfunction
inflammation
factor VIII
Von Willeband factor
chronic graft-versus-host disease (cGvHD)
allogeneic hematopoietic stem cell transplantation
author_facet Antonela Lelas
Hildegard Theresia Greinix
Daniel Wolff
Günther Eissner
Steven Zivko Pavletic
Drazen Pulanic
Drazen Pulanic
author_sort Antonela Lelas
title Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
title_short Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
title_full Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
title_fullStr Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
title_full_unstemmed Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease
title_sort von willebrand factor, factor viii, and other acute phase reactants as biomarkers of inflammation and endothelial dysfunction in chronic graft-versus-host disease
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2021-04-01
description Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.
topic endothelial dysfunction
inflammation
factor VIII
Von Willeband factor
chronic graft-versus-host disease (cGvHD)
allogeneic hematopoietic stem cell transplantation
url https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/full
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