Extrauterine Low-Grade Endometrial Stromal Sarcoma
Objective: Endometrial stromal sarcoma is a rare cancer that accounts for 0.2% or less of all female genital tract malignancies. We present a case of extrauterine low-grade endometrial stromal sarcoma arising from endometriosis, which was managed by unilateral salpingo-oophorectomy with postoperativ...
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doaj-61561235e98d4779a9dd5e2fac6c22782020-11-25T02:19:44ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592005-12-0144438739010.1016/S1028-4559(09)60181-9Extrauterine Low-Grade Endometrial Stromal SarcomaYu-Ju Chen0Esther Shih-Chu Ho1Fu-Shing Liu2Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, TaiwanObjective: Endometrial stromal sarcoma is a rare cancer that accounts for 0.2% or less of all female genital tract malignancies. We present a case of extrauterine low-grade endometrial stromal sarcoma arising from endometriosis, which was managed by unilateral salpingo-oophorectomy with postoperative high-dose progesterone adjuvant therapy. Case Report: A 28-year-old nulligravid woman had suffered from progressive abdominal distension accompanied by a palpable firm mass for about 3 months. An abdominal pelvic mass, measuring 13 × 12 × 8 cm, was seen on pelvic sonography and abdominal computed tomography. The CA125 titer was also elevated. Left salpingo-oophorectomy was performed when frozen section examination of the tumor indicated a benign tumor. However, the pathology of the tumor was extrauterine low-grade endometrial stromal sarcoma with extensive endometrioid glandular differentiation arising from endometriosis. The resection margin was also involved. The patient has been receiving high-dose progesterone therapy for 2 months without any adverse effects, except for an increase in body weight of 2 kg. Conclusions: Low-grade endometrial stromal sarcoma typically has an indolent clinical course and favorable prognosis. Surgical resection is the primary therapeutic approach, and adjuvant therapy with radiotherapy, chemotherapy, or progesterone therapy should be considered for the management of residual or recurrent low-grade endometrial stromal sarcomas.http://www.sciencedirect.com/science/article/pii/S1028455909601819endometriosislow-grade endometrial stromal sarcomaprogesterone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Ju Chen Esther Shih-Chu Ho Fu-Shing Liu |
spellingShingle |
Yu-Ju Chen Esther Shih-Chu Ho Fu-Shing Liu Extrauterine Low-Grade Endometrial Stromal Sarcoma Taiwanese Journal of Obstetrics & Gynecology endometriosis low-grade endometrial stromal sarcoma progesterone |
author_facet |
Yu-Ju Chen Esther Shih-Chu Ho Fu-Shing Liu |
author_sort |
Yu-Ju Chen |
title |
Extrauterine Low-Grade Endometrial Stromal Sarcoma |
title_short |
Extrauterine Low-Grade Endometrial Stromal Sarcoma |
title_full |
Extrauterine Low-Grade Endometrial Stromal Sarcoma |
title_fullStr |
Extrauterine Low-Grade Endometrial Stromal Sarcoma |
title_full_unstemmed |
Extrauterine Low-Grade Endometrial Stromal Sarcoma |
title_sort |
extrauterine low-grade endometrial stromal sarcoma |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2005-12-01 |
description |
Objective: Endometrial stromal sarcoma is a rare cancer that accounts for 0.2% or less of all female genital tract malignancies. We present a case of extrauterine low-grade endometrial stromal sarcoma arising from endometriosis, which was managed by unilateral salpingo-oophorectomy with postoperative high-dose progesterone adjuvant therapy.
Case Report: A 28-year-old nulligravid woman had suffered from progressive abdominal distension accompanied by a palpable firm mass for about 3 months. An abdominal pelvic mass, measuring 13 × 12 × 8 cm, was seen on pelvic sonography and abdominal computed tomography. The CA125 titer was also elevated. Left salpingo-oophorectomy was performed when frozen section examination of the tumor indicated a benign tumor. However, the pathology of the tumor was extrauterine low-grade endometrial stromal sarcoma with extensive endometrioid glandular differentiation arising from endometriosis. The resection margin was also involved. The patient has been receiving high-dose progesterone therapy for 2 months without any adverse effects, except for an increase in body weight of 2 kg.
Conclusions: Low-grade endometrial stromal sarcoma typically has an indolent clinical course and favorable prognosis. Surgical resection is the primary therapeutic approach, and adjuvant therapy with radiotherapy, chemotherapy, or progesterone therapy should be considered for the management of residual or recurrent low-grade endometrial stromal sarcomas. |
topic |
endometriosis low-grade endometrial stromal sarcoma progesterone |
url |
http://www.sciencedirect.com/science/article/pii/S1028455909601819 |
work_keys_str_mv |
AT yujuchen extrauterinelowgradeendometrialstromalsarcoma AT esthershihchuho extrauterinelowgradeendometrialstromalsarcoma AT fushingliu extrauterinelowgradeendometrialstromalsarcoma |
_version_ |
1724874665604677632 |