Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells

Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells

A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel...

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Bibliographic Details
Main Authors: Qiaohuang Zeng, Feifei Qiu, Yuchao Chen, Cuihua Liu, Huazhen Liu, Chun-Ling Liang, Qunfang Zhang, Zhenhua Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
allograft rejection
immunosuppresant
immunoregulation
Treg
T cell
transplant immunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00652/full

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