Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly. While advancements have been made in understanding the genetic and molecular basis of AD, the clinical diagnosis of AD remains difficult and post-mortem confirmation is often required. Furthermore, the onset of neu...
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doaj-616799d15edf43c9a6a98a43fd814fd42020-11-24T21:04:30ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992013-08-01610.3389/fnmol.2013.0002458160Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkersVeronique eDorval0Veronique eDorval1Peter T Nelson2Sébastien S Hébert3Sébastien S Hébert4Université LavalCentre de recherche du CHU de Quebec (CHUL)University of KentuckyUniversité LavalCentre de recherche du CHU de Quebec (CHUL)Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly. While advancements have been made in understanding the genetic and molecular basis of AD, the clinical diagnosis of AD remains difficult and post-mortem confirmation is often required. Furthermore, the onset of neurodegeneration precedes clinical symptoms by approximately a decade. Consequently, there is a crucial need for an early and accurate diagnosis of AD, which can potentially lead to strategies that can slow down or stop the progression of neurodegeneration and dementia. Recent advances in the noncoding RNA field have shown that microRNAs (miRNAs) can function as powerful biomarkers in human diseases. Studies are emerging suggesting that circulating miRNAs in the cerebrospinal fluid (CSF) and blood serum have characteristic changes in AD patients. Whether miRNAs can be used in AD diagnosis, alone or in combination with other AD biomarkers (e.g., amyloid and tau), warrants further investigation.http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00024/fullMild Cognitive ImpairmentAlzheimer's diseasemicroRNAbiomarkerdiagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Veronique eDorval Veronique eDorval Peter T Nelson Sébastien S Hébert Sébastien S Hébert |
spellingShingle |
Veronique eDorval Veronique eDorval Peter T Nelson Sébastien S Hébert Sébastien S Hébert Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers Frontiers in Molecular Neuroscience Mild Cognitive Impairment Alzheimer's disease microRNA biomarker diagnosis |
author_facet |
Veronique eDorval Veronique eDorval Peter T Nelson Sébastien S Hébert Sébastien S Hébert |
author_sort |
Veronique eDorval |
title |
Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers |
title_short |
Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers |
title_full |
Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers |
title_fullStr |
Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers |
title_full_unstemmed |
Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers |
title_sort |
circulating micrornas in alzheimer’s disease: the search for novel biomarkers |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Neuroscience |
issn |
1662-5099 |
publishDate |
2013-08-01 |
description |
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly. While advancements have been made in understanding the genetic and molecular basis of AD, the clinical diagnosis of AD remains difficult and post-mortem confirmation is often required. Furthermore, the onset of neurodegeneration precedes clinical symptoms by approximately a decade. Consequently, there is a crucial need for an early and accurate diagnosis of AD, which can potentially lead to strategies that can slow down or stop the progression of neurodegeneration and dementia. Recent advances in the noncoding RNA field have shown that microRNAs (miRNAs) can function as powerful biomarkers in human diseases. Studies are emerging suggesting that circulating miRNAs in the cerebrospinal fluid (CSF) and blood serum have characteristic changes in AD patients. Whether miRNAs can be used in AD diagnosis, alone or in combination with other AD biomarkers (e.g., amyloid and tau), warrants further investigation. |
topic |
Mild Cognitive Impairment Alzheimer's disease microRNA biomarker diagnosis |
url |
http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00024/full |
work_keys_str_mv |
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1716770860168118272 |