HPV infections and flat penile lesions of the penis in men who have sex with men
Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and...
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doaj-616ce7884937451687136b74f2bd6cf82020-11-24T21:55:21ZengElsevierPapillomavirus Research2405-85212019-12-018HPV infections and flat penile lesions of the penis in men who have sex with menWard P.H. Van Bilsen0Alexandra Kovaleva1Maaike C.G. Bleeker2Audrey J. King3Sylvia M. Bruisten4Wilma Brokking5Henry J.C. De Vries6Chris J.L.M. Meijer7Maarten F. Schim Van Der Loeff8Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands; Corresponding author. Public Health Service of Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, 1018 WT, Amsterdam the Netherlands.Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the NetherlandsDepartment of Pathology, Amsterdam UMC, Vrije Universiteit-University Medical Center, Amsterdam, the NetherlandsCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the NetherlandsDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands; Amsterdam Infection & Immunity Institute (AIII), Amsterdam UMC, Academic Medical Center, Amsterdam, the NetherlandsDepartment of Internal Medicine, DC Klinieken, Amsterdam, the NetherlandsDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands; Department of Dermatology, Amsterdam UMC, Academic Medical Center, Amsterdam, the NetherlandsDepartment of Pathology, Amsterdam UMC, Vrije Universiteit-University Medical Center, Amsterdam, the NetherlandsDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands; Amsterdam Infection & Immunity Institute (AIII), Amsterdam UMC, Academic Medical Center, Amsterdam, the NetherlandsBackground: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status. Keywords: Flat penile lesion, Human papillomavirus, Men who have sex with men, HIVhttp://www.sciencedirect.com/science/article/pii/S2405852119300278 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ward P.H. Van Bilsen Alexandra Kovaleva Maaike C.G. Bleeker Audrey J. King Sylvia M. Bruisten Wilma Brokking Henry J.C. De Vries Chris J.L.M. Meijer Maarten F. Schim Van Der Loeff |
spellingShingle |
Ward P.H. Van Bilsen Alexandra Kovaleva Maaike C.G. Bleeker Audrey J. King Sylvia M. Bruisten Wilma Brokking Henry J.C. De Vries Chris J.L.M. Meijer Maarten F. Schim Van Der Loeff HPV infections and flat penile lesions of the penis in men who have sex with men Papillomavirus Research |
author_facet |
Ward P.H. Van Bilsen Alexandra Kovaleva Maaike C.G. Bleeker Audrey J. King Sylvia M. Bruisten Wilma Brokking Henry J.C. De Vries Chris J.L.M. Meijer Maarten F. Schim Van Der Loeff |
author_sort |
Ward P.H. Van Bilsen |
title |
HPV infections and flat penile lesions of the penis in men who have sex with men |
title_short |
HPV infections and flat penile lesions of the penis in men who have sex with men |
title_full |
HPV infections and flat penile lesions of the penis in men who have sex with men |
title_fullStr |
HPV infections and flat penile lesions of the penis in men who have sex with men |
title_full_unstemmed |
HPV infections and flat penile lesions of the penis in men who have sex with men |
title_sort |
hpv infections and flat penile lesions of the penis in men who have sex with men |
publisher |
Elsevier |
series |
Papillomavirus Research |
issn |
2405-8521 |
publishDate |
2019-12-01 |
description |
Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status. Keywords: Flat penile lesion, Human papillomavirus, Men who have sex with men, HIV |
url |
http://www.sciencedirect.com/science/article/pii/S2405852119300278 |
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