Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative

Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative

The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the success...

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Bibliographic Details
Main Authors: Yu Mi Heo, Hunseok Lee, Young Kee Shin, Seung-Mann Paek
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
macrosphelides
natural product
total synthesis
Online Access:http://www.mdpi.com/1420-3049/19/10/15572

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