Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation
Ubiquitination is a post-translational modification that defines the cellular fate of intracellular proteins. It can modify their stability, their activity, their subcellular location, and even their interacting pattern. This modification is a reversible event whose implementation is easy and fast....
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doaj-6177a7ea47d34bc0a0134a60fec712732020-11-24T22:16:31ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-10-011810218810.3390/ijms18102188ijms18102188Regulation of E2F1 Transcription Factor by Ubiquitin ConjugationLaurence Dubrez0Université de Bourgogne Franche-Comté, LNC UMR1231, 21000 Dijon, FranceUbiquitination is a post-translational modification that defines the cellular fate of intracellular proteins. It can modify their stability, their activity, their subcellular location, and even their interacting pattern. This modification is a reversible event whose implementation is easy and fast. It contributes to the rapid adaptation of the cells to physiological intracellular variations and to intracellular or environmental stresses. E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. Its expression and activity are tightly regulated over the course of the cell cycle progression and in response to genotoxic stress. I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1’s regulation.https://www.mdpi.com/1422-0067/18/10/2188E2F1ubiquitinationcell cycleDNA damage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laurence Dubrez |
spellingShingle |
Laurence Dubrez Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation International Journal of Molecular Sciences E2F1 ubiquitination cell cycle DNA damage |
author_facet |
Laurence Dubrez |
author_sort |
Laurence Dubrez |
title |
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation |
title_short |
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation |
title_full |
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation |
title_fullStr |
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation |
title_full_unstemmed |
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation |
title_sort |
regulation of e2f1 transcription factor by ubiquitin conjugation |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-10-01 |
description |
Ubiquitination is a post-translational modification that defines the cellular fate of intracellular proteins. It can modify their stability, their activity, their subcellular location, and even their interacting pattern. This modification is a reversible event whose implementation is easy and fast. It contributes to the rapid adaptation of the cells to physiological intracellular variations and to intracellular or environmental stresses. E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. Its expression and activity are tightly regulated over the course of the cell cycle progression and in response to genotoxic stress. I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1’s regulation. |
topic |
E2F1 ubiquitination cell cycle DNA damage |
url |
https://www.mdpi.com/1422-0067/18/10/2188 |
work_keys_str_mv |
AT laurencedubrez regulationofe2f1transcriptionfactorbyubiquitinconjugation |
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1725789330049335296 |