Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve
Research on dance interventions (DIs) in the elderly has shown promising benefits to physical and cognitive outcomes. The effect of DIs on resting-state functional connectivity (rs-FC) varies, which is possibly due to individual variability. In this study, we assessed the moderation effects of resid...
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2021-09-01
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doaj-6179b4a33de6447093a5e66ad83dcb922021-09-10T12:13:00ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-09-011310.3389/fnagi.2021.724094724094Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive ReserveKristína Mitterová0Kristína Mitterová1Martin Lamoš2Radek Mareček3Monika Pupíková4Monika Pupíková5Patrik Šimko6Patrik Šimko7Roman Grmela8Alena Skotáková9Pavlína Vaculíková10Irena Rektorová11Irena Rektorová12Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaBrain and Mind Research Program, Central European Institute of Technology, Masaryk University, Brno, CzechiaBrain and Mind Research Program, Central European Institute of Technology, Masaryk University, Brno, CzechiaApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaDepartment of Health Promotion, Faculty of Sports Studies, Masaryk University, Brno, CzechiaDepartment of Gymnastics and Combatives, Faculty of Sports Studies, Masaryk University, Brno, CzechiaDepartment of Gymnastics and Combatives, Faculty of Sports Studies, Masaryk University, Brno, CzechiaApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, CzechiaFirst Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, CzechiaResearch on dance interventions (DIs) in the elderly has shown promising benefits to physical and cognitive outcomes. The effect of DIs on resting-state functional connectivity (rs-FC) varies, which is possibly due to individual variability. In this study, we assessed the moderation effects of residual cognitive reserve (CR) on DI-induced changes in dynamic rs-FC and their association on cognitive outcomes. Dynamic rs-FC (rs-dFC) and cognitive functions were evaluated in non-demented elderly subjects before and after a 6-month DI (n = 36) and a control group, referred to as the life-as-usual (LAU) group (n = 32). Using linear mixed models and moderation, we examined the interaction effect of DIs and CR on changes in the dwell time and coverage of rs-dFC. Cognitive reserve was calculated as the residual difference between the observed memory performance and the performance predicted by brain state. Partial correlations accounting for CR evaluated the unique association between changes in rs-dFC and cognition in the DI group. In subjects with lower residual CR, we observed DI-induced increases in dwell time [t(58) = –2.14, p = 0.036] and coverage [t(58) = –2.22, p = 0.030] of a rs-dFC state, which was implicated in bottom-up information processing. Increased dwell time was also correlated with a DI-induced improvement in Symbol Search (r = 0.42, p = 0.02). In subjects with higher residual CR, we observed a DI-induced increase in coverage [t(58) = 2.11, p = 0.039] of another rs-dFC state, which was implicated in top-down information processing. The study showed that DIs have a differential and behaviorally relevant effect on dynamic rs-dFC, but these benefits depend on the current CR level.https://www.frontiersin.org/articles/10.3389/fnagi.2021.724094/fullcognitive reservedance interventiondynamic resting-state functional connectivityattentionbottom-up processingtop-down processing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kristína Mitterová Kristína Mitterová Martin Lamoš Radek Mareček Monika Pupíková Monika Pupíková Patrik Šimko Patrik Šimko Roman Grmela Alena Skotáková Pavlína Vaculíková Irena Rektorová Irena Rektorová |
spellingShingle |
Kristína Mitterová Kristína Mitterová Martin Lamoš Radek Mareček Monika Pupíková Monika Pupíková Patrik Šimko Patrik Šimko Roman Grmela Alena Skotáková Pavlína Vaculíková Irena Rektorová Irena Rektorová Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve Frontiers in Aging Neuroscience cognitive reserve dance intervention dynamic resting-state functional connectivity attention bottom-up processing top-down processing |
author_facet |
Kristína Mitterová Kristína Mitterová Martin Lamoš Radek Mareček Monika Pupíková Monika Pupíková Patrik Šimko Patrik Šimko Roman Grmela Alena Skotáková Pavlína Vaculíková Irena Rektorová Irena Rektorová |
author_sort |
Kristína Mitterová |
title |
Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve |
title_short |
Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve |
title_full |
Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve |
title_fullStr |
Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve |
title_full_unstemmed |
Dynamic Functional Connectivity Signifies the Joint Impact of Dance Intervention and Cognitive Reserve |
title_sort |
dynamic functional connectivity signifies the joint impact of dance intervention and cognitive reserve |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-09-01 |
description |
Research on dance interventions (DIs) in the elderly has shown promising benefits to physical and cognitive outcomes. The effect of DIs on resting-state functional connectivity (rs-FC) varies, which is possibly due to individual variability. In this study, we assessed the moderation effects of residual cognitive reserve (CR) on DI-induced changes in dynamic rs-FC and their association on cognitive outcomes. Dynamic rs-FC (rs-dFC) and cognitive functions were evaluated in non-demented elderly subjects before and after a 6-month DI (n = 36) and a control group, referred to as the life-as-usual (LAU) group (n = 32). Using linear mixed models and moderation, we examined the interaction effect of DIs and CR on changes in the dwell time and coverage of rs-dFC. Cognitive reserve was calculated as the residual difference between the observed memory performance and the performance predicted by brain state. Partial correlations accounting for CR evaluated the unique association between changes in rs-dFC and cognition in the DI group. In subjects with lower residual CR, we observed DI-induced increases in dwell time [t(58) = –2.14, p = 0.036] and coverage [t(58) = –2.22, p = 0.030] of a rs-dFC state, which was implicated in bottom-up information processing. Increased dwell time was also correlated with a DI-induced improvement in Symbol Search (r = 0.42, p = 0.02). In subjects with higher residual CR, we observed a DI-induced increase in coverage [t(58) = 2.11, p = 0.039] of another rs-dFC state, which was implicated in top-down information processing. The study showed that DIs have a differential and behaviorally relevant effect on dynamic rs-dFC, but these benefits depend on the current CR level. |
topic |
cognitive reserve dance intervention dynamic resting-state functional connectivity attention bottom-up processing top-down processing |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.724094/full |
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