COX-2 Inhibitors for Cancer Treatment in Dogs
Cancer is one of the main causes of death in canines and felines, and this fact is probably related to the increase in the longevity of these species. The longer the animals live, the higher the exposure to carcinogenic agents will be. With the high incidence of cancer in companion animals, new stud...
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University of Agriculture, Faisalabad
2011-10-01
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doaj-617a0be99640422b9dd760574b7239742020-11-24T20:48:07ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182011-10-01314275279COX-2 Inhibitors for Cancer Treatment in DogsAndrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3Cancer is one of the main causes of death in canines and felines, and this fact is probably related to the increase in the longevity of these species. The longer the animals live, the higher the exposure to carcinogenic agents will be. With the high incidence of cancer in companion animals, new studies are currently being performed with the aim of finding therapeutic options which make the complete inhibition of the development of neoplasms in animals possible in the future. The correlation of cyclooxygenase-2 (COX-2) whith the development of cancer opens the way for the use of new therapeutic approaches. This relationship has been suggested based on various studies which established an association between the chronic use of nonsteroidal anti-inflammatory drugs (NSAID) and a decrease in the incidence of colon carcinoma. As cancer progresses, COX-2 participates in the arachidonic acid metabolism by synthesizing prostaglandins which can mediate various mechanisms related to cancer development such as: increase in angiogenesis, inhibition of apoptosis, suppression of the immune response, acquisition of greater invasion capacity and metastasis. Accordingly, overexpression of this enzyme in tumors has been associated with the most aggressive, poor-prognosis cancer types, especially carcinomas. Therefore, treatments which use COX-2 inhibitors such as coxibs, whether administered as single agents or in combination with conventional antineoplastic chemotherapy, are an alternative for extending the survival of our cancer patients.http://pvj.com.pk/pdf-files/31_4/275-279.pdfCanineCoxibsCyclooxygenase-2Tumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3 |
spellingShingle |
Andrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3 COX-2 Inhibitors for Cancer Treatment in Dogs Pakistan Veterinary Journal Canine Coxibs Cyclooxygenase-2 Tumor |
author_facet |
Andrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3 |
author_sort |
Andrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3 |
title |
COX-2 Inhibitors for Cancer Treatment in Dogs |
title_short |
COX-2 Inhibitors for Cancer Treatment in Dogs |
title_full |
COX-2 Inhibitors for Cancer Treatment in Dogs |
title_fullStr |
COX-2 Inhibitors for Cancer Treatment in Dogs |
title_full_unstemmed |
COX-2 Inhibitors for Cancer Treatment in Dogs |
title_sort |
cox-2 inhibitors for cancer treatment in dogs |
publisher |
University of Agriculture, Faisalabad |
series |
Pakistan Veterinary Journal |
issn |
0253-8318 |
publishDate |
2011-10-01 |
description |
Cancer is one of the main causes of death in canines and felines, and this fact is probably related to the increase in the longevity of these species. The longer the animals live, the higher the exposure to carcinogenic agents will be. With the high incidence of cancer in companion animals, new studies are currently being performed with the aim of finding therapeutic options which make the complete inhibition of the development of neoplasms in animals possible in the future. The correlation of cyclooxygenase-2 (COX-2) whith the development of cancer opens the way for the use of new therapeutic approaches. This relationship has been suggested based on various studies which established an association between the chronic use of nonsteroidal anti-inflammatory drugs (NSAID) and a decrease in the incidence of colon carcinoma. As cancer progresses, COX-2 participates in the arachidonic acid metabolism by synthesizing prostaglandins which can mediate various mechanisms related to cancer development such as: increase in angiogenesis, inhibition of apoptosis, suppression of the immune response, acquisition of greater invasion capacity and metastasis. Accordingly, overexpression of this enzyme in tumors has been associated with the most aggressive, poor-prognosis cancer types, especially carcinomas. Therefore, treatments which use COX-2 inhibitors such as coxibs, whether administered as single agents or in combination with conventional antineoplastic chemotherapy, are an alternative for extending the survival of our cancer patients. |
topic |
Canine Coxibs Cyclooxygenase-2 Tumor |
url |
http://pvj.com.pk/pdf-files/31_4/275-279.pdf |
work_keys_str_mv |
AT andrigobarbozadenarditalitamarianamorataraposo1rafaelricardohuppes1carlosrobertodaleck2andreneelauferamorim3 cox2inhibitorsforcancertreatmentindogs |
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