MyD88 promotes myoblast fusion in a cell-autonomous manner
Myoblast fusion is essential for skeletal muscle development and regeneration. Here the authors show that MyD88 is upregulated during myogenesis and during muscle growth, signals via the NF-κB and Wnt pathways, and that its expression modulates myoblast fusion and myofiber size in mice.
Main Authors: | Sajedah M. Hindi, Jonghyun Shin, Yann S. Gallot, Alex R. Straughn, Adriana Simionescu-Bankston, Lubna Hindi, Guangyan Xiong, Robert P. Friedland, Ashok Kumar |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-11-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-01866-w |
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