Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease
The International Mouse Phenotyping Consortium (IMPC) is a major international effort to explore the effects of knocking out 20,000 genes in the mouse. A new study by White and colleagues, published in the current issue of Disease Models & Mechanisms, demonstrates the usefulness of lacZ in situ...
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2015-11-01
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doaj-61900bbd5e554876bd218e0256aba6332020-11-25T00:45:25ZengThe Company of BiologistsDisease Models & Mechanisms1754-84111754-84032015-11-018111341134310.1242/dmm.023606023606Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human diseaseChris Armit0 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK The International Mouse Phenotyping Consortium (IMPC) is a major international effort to explore the effects of knocking out 20,000 genes in the mouse. A new study by White and colleagues, published in the current issue of Disease Models & Mechanisms, demonstrates the usefulness of lacZ in situ reporter expression patterns in extending our understanding of genotype-phenotype relationships as part of the IMPC high-throughput screen. In situ gene expression profiling is invaluable for evaluating compartment-specific gene expression patterns, and these enrich our understanding of the role of genes in a great number of biological processes in multiple organ systems. Furthermore, the complexity of gene expression patterns informs our understanding of how genes influence lethality. This Editorial aims to highlight ways in which the lacZ expression profiles can impact on biomedical research by uncovering as-yet-unknown genotype-phenotype relationships, and through predicting the role of genes in health and disease.http://dmm.biologists.org/content/8/11/1341Gene expressionlacZMouse |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chris Armit |
spellingShingle |
Chris Armit Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease Disease Models & Mechanisms Gene expression lacZ Mouse |
author_facet |
Chris Armit |
author_sort |
Chris Armit |
title |
Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease |
title_short |
Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease |
title_full |
Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease |
title_fullStr |
Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease |
title_full_unstemmed |
Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease |
title_sort |
into the blue: the importance of murine lacz gene expression profiling in understanding and treating human disease |
publisher |
The Company of Biologists |
series |
Disease Models & Mechanisms |
issn |
1754-8411 1754-8403 |
publishDate |
2015-11-01 |
description |
The International Mouse Phenotyping Consortium (IMPC) is a major international effort to explore the effects of knocking out 20,000 genes in the mouse. A new study by White and colleagues, published in the current issue of Disease Models & Mechanisms, demonstrates the usefulness of lacZ in situ reporter expression patterns in extending our understanding of genotype-phenotype relationships as part of the IMPC high-throughput screen. In situ gene expression profiling is invaluable for evaluating compartment-specific gene expression patterns, and these enrich our understanding of the role of genes in a great number of biological processes in multiple organ systems. Furthermore, the complexity of gene expression patterns informs our understanding of how genes influence lethality. This Editorial aims to highlight ways in which the lacZ expression profiles can impact on biomedical research by uncovering as-yet-unknown genotype-phenotype relationships, and through predicting the role of genes in health and disease. |
topic |
Gene expression lacZ Mouse |
url |
http://dmm.biologists.org/content/8/11/1341 |
work_keys_str_mv |
AT chrisarmit intothebluetheimportanceofmurinelaczgeneexpressionprofilinginunderstandingandtreatinghumandisease |
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