Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>

Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>

Antipathogenic compounds that target the virulence of pathogenic bacteria rather than their viability offer a promising alternative approach to treat infectious diseases. Using extracts from 30 Chinese herbs that are known for treating symptoms resembling infections, we identified an active compound...

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Main Authors: Pansong Zhang, Qiaolian Wu, Lin Chen, Kangmin Duan
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Antibiotics
Subjects:
<i>pseudomonas aeruginosa</i>
falcarindiol
anti-virulence therapeutic
type iii secretion system
antibiotics
quorum sensing
Online Access:https://www.mdpi.com/2079-6382/9/3/136
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spelling doaj-6191e83b304c48cabbb87bf928754bb52020-11-25T01:44:36ZengMDPI AGAntibiotics2079-63822020-03-019313610.3390/antibiotics9030136antibiotics9030136Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>Pansong Zhang0Qiaolian Wu1Lin Chen2Kangmin Duan3Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi’an 710069, ChinaKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi’an 710069, ChinaKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi’an 710069, ChinaDepartment of Oral Biology &amp; Medical Microbiology &amp; Infectious Diseases, Rady Faculty of Health Sciences, University of Manitoba, 780 Bannatyne Ave., Winnipeg, MB R3E 0W2, CanadaAntipathogenic compounds that target the virulence of pathogenic bacteria rather than their viability offer a promising alternative approach to treat infectious diseases. Using extracts from 30 Chinese herbs that are known for treating symptoms resembling infections, we identified an active compound falcarindiol from <i>Notopterygium incisum</i> Ting ex H. T. Chang that showed potent inhibitory activities against <i>Pseudomonas aeruginosa</i> multiple virulence factors. Falcarindiol significantly repressed virulence-related genes, including the type III secretion system (T3SS); quorum sensing synthase genes <i>lasIR</i> and <i>rhlIR</i>; <i>lasB</i>; motility-related genes <i>fliC</i> and <i>fliG</i>; and phenazine synthesis genes <i>phzA1</i> and <i>phzA2. P. aeruginosa</i> swarming motility and pyocyanin production were reduced significantly. In a burned mouse model, falcarindiol treatment significantly reduced the mortality in mice infected with <i>P. aeruginosa,</i> indicating that falcarindiol is a promising antipathogenic drug candidate for treating <i>P. aeruginosa</i> infections.https://www.mdpi.com/2079-6382/9/3/136<i>pseudomonas aeruginosa</i>falcarindiolanti-virulence therapeutictype iii secretion systemantibioticsquorum sensing
collection DOAJ
language English
format Article
sources DOAJ
author Pansong Zhang
Qiaolian Wu
Lin Chen
Kangmin Duan
spellingShingle Pansong Zhang
Qiaolian Wu
Lin Chen
Kangmin Duan
Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>
Antibiotics
<i>pseudomonas aeruginosa</i>
falcarindiol
anti-virulence therapeutic
type iii secretion system
antibiotics
quorum sensing
author_facet Pansong Zhang
Qiaolian Wu
Lin Chen
Kangmin Duan
author_sort Pansong Zhang
title Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>
title_short Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>
title_full Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>
title_fullStr Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>
title_full_unstemmed Virulence-Inhibiting Herbal Compound Falcarindiol Significantly Reduced Mortality in Mice Infected with <i>Pseudomonas aeruginosa</i>
title_sort virulence-inhibiting herbal compound falcarindiol significantly reduced mortality in mice infected with <i>pseudomonas aeruginosa</i>
publisher MDPI AG
series Antibiotics
issn 2079-6382
publishDate 2020-03-01
description Antipathogenic compounds that target the virulence of pathogenic bacteria rather than their viability offer a promising alternative approach to treat infectious diseases. Using extracts from 30 Chinese herbs that are known for treating symptoms resembling infections, we identified an active compound falcarindiol from <i>Notopterygium incisum</i> Ting ex H. T. Chang that showed potent inhibitory activities against <i>Pseudomonas aeruginosa</i> multiple virulence factors. Falcarindiol significantly repressed virulence-related genes, including the type III secretion system (T3SS); quorum sensing synthase genes <i>lasIR</i> and <i>rhlIR</i>; <i>lasB</i>; motility-related genes <i>fliC</i> and <i>fliG</i>; and phenazine synthesis genes <i>phzA1</i> and <i>phzA2. P. aeruginosa</i> swarming motility and pyocyanin production were reduced significantly. In a burned mouse model, falcarindiol treatment significantly reduced the mortality in mice infected with <i>P. aeruginosa,</i> indicating that falcarindiol is a promising antipathogenic drug candidate for treating <i>P. aeruginosa</i> infections.
topic <i>pseudomonas aeruginosa</i>
falcarindiol
anti-virulence therapeutic
type iii secretion system
antibiotics
quorum sensing
url https://www.mdpi.com/2079-6382/9/3/136
work_keys_str_mv AT pansongzhang virulenceinhibitingherbalcompoundfalcarindiolsignificantlyreducedmortalityinmiceinfectedwithipseudomonasaeruginosai
AT qiaolianwu virulenceinhibitingherbalcompoundfalcarindiolsignificantlyreducedmortalityinmiceinfectedwithipseudomonasaeruginosai
AT linchen virulenceinhibitingherbalcompoundfalcarindiolsignificantlyreducedmortalityinmiceinfectedwithipseudomonasaeruginosai
AT kangminduan virulenceinhibitingherbalcompoundfalcarindiolsignificantlyreducedmortalityinmiceinfectedwithipseudomonasaeruginosai
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