Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity
The use of the transdermal contraceptive patch is associated with greater bioavailability of ethinyl estradiol (EE) compared with contraceptive vaginal ring or oral contraceptives (OC). We compared the influences of three contraceptive methods (OC, vaginal ring, and transdermal patch) on serum level...
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Online Access: | http://dx.doi.org/10.1155/2010/925635 |
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doaj-6192f118b6d94b1da58b8c67476684202020-11-24T22:41:44ZengHindawi LimitedObstetrics and Gynecology International1687-95891687-95972010-01-01201010.1155/2010/925635925635Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant ActivityPrabhudas R. Palan0Felix Strube1Juraj Letko2Azra Sadikovic3Magdy S. Mikhail4Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, 1650 Grand Concourse, Bronx, NY 10457, USAThe use of the transdermal contraceptive patch is associated with greater bioavailability of ethinyl estradiol (EE) compared with contraceptive vaginal ring or oral contraceptives (OC). We compared the influences of three contraceptive methods (OC, vaginal ring, and transdermal patch) on serum levels of coenzyme Q10, α-tocopherol, γ-tocopherol and total antioxidant capacity in premenopausal women. Blood samples from 30 premenopausal women who used hormonal contraception for at least 4 months were collected. Forty subjects who did not use any contraception were studied as control. Serum levels of coenzyme Q10, α-tocopherol and γ-tocopherol were measured by high-pressure liquid chromatography. Serum samples were also assayed for total antioxidant capacity (TAOC). Serum levels of coenzyme Q10 and α-tocopherol were found to be significantly lower (P<.05) in all three contraceptive users compared with controls. Contraceptive patch users had the lowest levels of coenzyme Q10 levels compared with normal subjects. Serum TAOC levels were significantly lower (P<.05) among the contraceptive user groups. Alterations in coenzyme Q10 and α-tocopherol induced by hormonal contraception and the potential effect(s) of exogenous ovarian hormones should be taken into consideration in future antioxidant research.http://dx.doi.org/10.1155/2010/925635 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Prabhudas R. Palan Felix Strube Juraj Letko Azra Sadikovic Magdy S. Mikhail |
spellingShingle |
Prabhudas R. Palan Felix Strube Juraj Letko Azra Sadikovic Magdy S. Mikhail Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity Obstetrics and Gynecology International |
author_facet |
Prabhudas R. Palan Felix Strube Juraj Letko Azra Sadikovic Magdy S. Mikhail |
author_sort |
Prabhudas R. Palan |
title |
Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity |
title_short |
Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity |
title_full |
Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity |
title_fullStr |
Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity |
title_full_unstemmed |
Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant Activity |
title_sort |
effects of oral, vaginal, and transdermal hormonal contraception on serum levels of coenzyme q10, vitamin e, and total antioxidant activity |
publisher |
Hindawi Limited |
series |
Obstetrics and Gynecology International |
issn |
1687-9589 1687-9597 |
publishDate |
2010-01-01 |
description |
The use of the transdermal contraceptive patch is associated with greater bioavailability of ethinyl estradiol (EE) compared with contraceptive vaginal ring or oral contraceptives (OC). We compared the influences of three contraceptive methods (OC, vaginal ring, and transdermal patch) on serum levels of coenzyme Q10, α-tocopherol, γ-tocopherol and total antioxidant capacity in premenopausal women. Blood samples from 30 premenopausal women who used hormonal contraception for at least 4 months were collected. Forty subjects who did not use any contraception were studied as control. Serum levels of coenzyme Q10, α-tocopherol and γ-tocopherol were measured by high-pressure liquid chromatography. Serum samples were also assayed for total
antioxidant capacity (TAOC). Serum levels of coenzyme Q10 and α-tocopherol were found to be significantly lower (P<.05) in all three contraceptive users compared with controls. Contraceptive patch users had the lowest levels of
coenzyme Q10 levels compared with normal subjects. Serum TAOC levels were significantly lower (P<.05) among the contraceptive user groups. Alterations in coenzyme Q10 and α-tocopherol induced by hormonal contraception and the potential effect(s) of exogenous ovarian hormones should be taken into consideration in future antioxidant research. |
url |
http://dx.doi.org/10.1155/2010/925635 |
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