In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia

Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. od...

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Main Authors:	Louis Maes, Shaza M. Al-Massarani, Nawal M. Al Musayeib, Ramzi A. Mothana, Ali A. El Gamal
Format:	Article
Language:	English
Published:	MDPI AG 2013-07-01
Series:	Molecules
Subjects:	Kleinia odora triterpenes antiplasmodial antileishmanial antitrypanosomal
Online Access:	http://www.mdpi.com/1420-3049/18/8/9207

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spelling	doaj-6199514549a444568e040ebddd8cad342020-11-24T23:07:56ZengMDPI AGMolecules1420-30492013-07-011889207921810.3390/molecules18089207In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi ArabiaLouis MaesShaza M. Al-MassaraniNawal M. Al MusayeibRamzi A. MothanaAli A. El GamalTwo lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.http://www.mdpi.com/1420-3049/18/8/9207Kleinia odoratriterpenesantiplasmodialantileishmanialantitrypanosomal
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Louis Maes Shaza M. Al-Massarani Nawal M. Al Musayeib Ramzi A. Mothana Ali A. El Gamal
spellingShingle	Louis Maes Shaza M. Al-Massarani Nawal M. Al Musayeib Ramzi A. Mothana Ali A. El Gamal In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia Molecules Kleinia odora triterpenes antiplasmodial antileishmanial antitrypanosomal
author_facet	Louis Maes Shaza M. Al-Massarani Nawal M. Al Musayeib Ramzi A. Mothana Ali A. El Gamal
author_sort	Louis Maes
title	In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_short	In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_full	In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_fullStr	In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_full_unstemmed	In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_sort	in vitro antiprotozoal activity of triterpenoid constituents of kleinia odora growing in saudi arabia
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2013-07-01
description	Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.
topic	Kleinia odora triterpenes antiplasmodial antileishmanial antitrypanosomal
url	http://www.mdpi.com/1420-3049/18/8/9207
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In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia

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