In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. od...
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doaj-6199514549a444568e040ebddd8cad342020-11-24T23:07:56ZengMDPI AGMolecules1420-30492013-07-011889207921810.3390/molecules18089207In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi ArabiaLouis MaesShaza M. Al-MassaraniNawal M. Al MusayeibRamzi A. MothanaAli A. El GamalTwo lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.http://www.mdpi.com/1420-3049/18/8/9207Kleinia odoratriterpenesantiplasmodialantileishmanialantitrypanosomal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Louis Maes Shaza M. Al-Massarani Nawal M. Al Musayeib Ramzi A. Mothana Ali A. El Gamal |
spellingShingle |
Louis Maes Shaza M. Al-Massarani Nawal M. Al Musayeib Ramzi A. Mothana Ali A. El Gamal In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia Molecules Kleinia odora triterpenes antiplasmodial antileishmanial antitrypanosomal |
author_facet |
Louis Maes Shaza M. Al-Massarani Nawal M. Al Musayeib Ramzi A. Mothana Ali A. El Gamal |
author_sort |
Louis Maes |
title |
In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia |
title_short |
In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia |
title_full |
In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia |
title_fullStr |
In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia |
title_full_unstemmed |
In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia |
title_sort |
in vitro antiprotozoal activity of triterpenoid constituents of kleinia odora growing in saudi arabia |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2013-07-01 |
description |
Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei. |
topic |
Kleinia odora triterpenes antiplasmodial antileishmanial antitrypanosomal |
url |
http://www.mdpi.com/1420-3049/18/8/9207 |
work_keys_str_mv |
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