Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or internal globus pallidus (GPi) has been routinely used for the treatment of some movement disorders. However, DBS may be associated with adverse psychiatric effects, such as depression, anxiety and impulsivity. Objective: T...
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doaj-619d101bc9ff4ebe8865d55e5f89f0f82021-03-18T04:36:19ZengElsevierBrain Stimulation1935-861X2013-07-0164506514Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic NucleiMeaghan C. Creed0Clement Hamani1José N. Nobrega2Department of Pharmacology and Toxicology, University of Toronto, Canada; Research Imaging Centre, Center for Addiction and Mental Health, CanadaResearch Imaging Centre, Center for Addiction and Mental Health, Canada; Division of Neurosurgery, Toronto Western Hospital, University of Toronto, CanadaDepartment of Pharmacology and Toxicology, University of Toronto, Canada; Research Imaging Centre, Center for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada; Department of Psychology, University of Toronto, Canada; Corresponding author. Behavioral Neurobiology Laboratory, Center for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada. Tel.: +1 416 979 6917; fax: +1 416 979 4739.Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or internal globus pallidus (GPi) has been routinely used for the treatment of some movement disorders. However, DBS may be associated with adverse psychiatric effects, such as depression, anxiety and impulsivity. Objective: To compare DBS applied to the entopeduncular nucleus (EPN; the rodent homolog of the GPi) and STN in terms of their effects on depressive- and anxiety-like behavior in rats. Methods: DBS was applied for 21 days (4 h a day) to either the STN or EPN. Rats then underwent behavioral testing on learned helplessness and elevated plus maze tasks before being sacrificed for brain analyses of zif268, BDNF and trkB mRNA as well as BDNF protein levels. Results: Repeated DBS of the STN, but not of the EPN, led to impaired performance in the learned helplessness task, suggesting that STN-DBS induces or potentiates depressive-like behavior. There was no effect of DBS on elevated plus maze or on open field behavior. Repeated STN-DBS, but not EPN-DBS, led to decreased levels of BDNF and trkB mRNA in hippocampus. Acute stimulation of the STN or EPN resulted in similar changes in zif268 levels in several brain areas, except for the raphe where decreases were seen only after STB-DBS. Conclusions: Together these results indicate that the effects of STN- and EPN-DBS differ in behavioral and neurochemical respects. Results further suggest that the EPN may be a preferable target for clinical DBS when psychiatric side effects are considered insofar as it may be associated with a lower incidence of depressive-like behavior than the STN.http://www.sciencedirect.com/science/article/pii/S1935861X12001854High-frequency stimulationDeep brain stimulationInternal globus pallidusAnxietyDepressiontrkB |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meaghan C. Creed Clement Hamani José N. Nobrega |
spellingShingle |
Meaghan C. Creed Clement Hamani José N. Nobrega Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei Brain Stimulation High-frequency stimulation Deep brain stimulation Internal globus pallidus Anxiety Depression trkB |
author_facet |
Meaghan C. Creed Clement Hamani José N. Nobrega |
author_sort |
Meaghan C. Creed |
title |
Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei |
title_short |
Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei |
title_full |
Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei |
title_fullStr |
Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei |
title_full_unstemmed |
Effects of Repeated Deep Brain Stimulation on Depressive- and Anxiety-Like Behavior in Rats: Comparing Entopeduncular and Subthalamic Nuclei |
title_sort |
effects of repeated deep brain stimulation on depressive- and anxiety-like behavior in rats: comparing entopeduncular and subthalamic nuclei |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2013-07-01 |
description |
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or internal globus pallidus (GPi) has been routinely used for the treatment of some movement disorders. However, DBS may be associated with adverse psychiatric effects, such as depression, anxiety and impulsivity. Objective: To compare DBS applied to the entopeduncular nucleus (EPN; the rodent homolog of the GPi) and STN in terms of their effects on depressive- and anxiety-like behavior in rats. Methods: DBS was applied for 21 days (4 h a day) to either the STN or EPN. Rats then underwent behavioral testing on learned helplessness and elevated plus maze tasks before being sacrificed for brain analyses of zif268, BDNF and trkB mRNA as well as BDNF protein levels. Results: Repeated DBS of the STN, but not of the EPN, led to impaired performance in the learned helplessness task, suggesting that STN-DBS induces or potentiates depressive-like behavior. There was no effect of DBS on elevated plus maze or on open field behavior. Repeated STN-DBS, but not EPN-DBS, led to decreased levels of BDNF and trkB mRNA in hippocampus. Acute stimulation of the STN or EPN resulted in similar changes in zif268 levels in several brain areas, except for the raphe where decreases were seen only after STB-DBS. Conclusions: Together these results indicate that the effects of STN- and EPN-DBS differ in behavioral and neurochemical respects. Results further suggest that the EPN may be a preferable target for clinical DBS when psychiatric side effects are considered insofar as it may be associated with a lower incidence of depressive-like behavior than the STN. |
topic |
High-frequency stimulation Deep brain stimulation Internal globus pallidus Anxiety Depression trkB |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X12001854 |
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