Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients
Uncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during th...
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doaj-619e7575673f498296ff34356013b2a72020-11-25T04:01:10ZengSAGE PublishingCell Transplantation0963-68971555-38922012-01-012110.3727/096368912X633770Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS PatientsG. A. Moviglia0M. T. Moviglia-Brandolino1G. S. Varela2G. Albanese3S. Piccone4G. Echegaray5G. Martinez6N. Blasseti7J. Farias8P. Farina9A. Perusso10C. A. Gaeta11CIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaCIITT, Maimonides University, Buenos Aires, ArgentinaUncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during the late 1970s and has been demonstrated to be an effective treatment for human autoimmune diseases and a regulator of macrophage activation in animal models. We treated seven ALS patients with this cell therapy and were able to slow or stop disease progression in the affected individuals. The median survival, which is 3.5 years, was extended to 6 years. They were also treated with autologous adult neural stem cells associated with effector T cells. The observed neurologic improvements after treatment lasted for at least 1 year. Clinical recovery in the treated ALS patients was confirmed by an independent, skilled neurologist using the ALS Functional Rating Scale-Revised (ALSFRS-R). TCV in conjunction with an autologous neural stem cell treatment might be a feasible, minimally invasive, safe, and effective approach to obtain enduring therapeutic effects in ALS patients.https://doi.org/10.3727/096368912X633770 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
G. A. Moviglia M. T. Moviglia-Brandolino G. S. Varela G. Albanese S. Piccone G. Echegaray G. Martinez N. Blasseti J. Farias P. Farina A. Perusso C. A. Gaeta |
spellingShingle |
G. A. Moviglia M. T. Moviglia-Brandolino G. S. Varela G. Albanese S. Piccone G. Echegaray G. Martinez N. Blasseti J. Farias P. Farina A. Perusso C. A. Gaeta Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients Cell Transplantation |
author_facet |
G. A. Moviglia M. T. Moviglia-Brandolino G. S. Varela G. Albanese S. Piccone G. Echegaray G. Martinez N. Blasseti J. Farias P. Farina A. Perusso C. A. Gaeta |
author_sort |
G. A. Moviglia |
title |
Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients |
title_short |
Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients |
title_full |
Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients |
title_fullStr |
Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients |
title_full_unstemmed |
Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients |
title_sort |
feasibility, safety, and preliminary proof of principles of autologous neural stem cell treatment combined with t-cell vaccination for als patients |
publisher |
SAGE Publishing |
series |
Cell Transplantation |
issn |
0963-6897 1555-3892 |
publishDate |
2012-01-01 |
description |
Uncontrolled activation of the innate immune system promotes the deterioration of neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at the Weizmann Institute of Science (Israel) during the late 1970s and has been demonstrated to be an effective treatment for human autoimmune diseases and a regulator of macrophage activation in animal models. We treated seven ALS patients with this cell therapy and were able to slow or stop disease progression in the affected individuals. The median survival, which is 3.5 years, was extended to 6 years. They were also treated with autologous adult neural stem cells associated with effector T cells. The observed neurologic improvements after treatment lasted for at least 1 year. Clinical recovery in the treated ALS patients was confirmed by an independent, skilled neurologist using the ALS Functional Rating Scale-Revised (ALSFRS-R). TCV in conjunction with an autologous neural stem cell treatment might be a feasible, minimally invasive, safe, and effective approach to obtain enduring therapeutic effects in ALS patients. |
url |
https://doi.org/10.3727/096368912X633770 |
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