Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor [version 2; referees: 2 approved]

Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor [version 2; referees: 2 approved]

Background: The ability of ErbB3 receptor to functionally complement ErbB1-2 and induce tumor resistance to their inhibitors makes it a unique target in cancer therapy by monoclonal antibodies. Here we report the expression, purification and structural analysis of a new anti-ErbB3 single-chain antib...

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Bibliographic Details
Main Authors: Igor E. Eliseev, Anna N. Yudenko, Vera V. Vysochinskaya, Anna A. Svirina, Anna V. Evstratyeva, Maria S. Drozhzhachih, Elena A. Krendeleva, Anna K. Vladimirova, Timofey A. Nemankin, Viktoria M. Ekimova, Andrey B. Ulitin, Maria I. Lomovskaya, Pavel A. Yakovlev, Anton S. Bukatin, Nickolay A. Knyazev, Fedor V. Moiseenko, Oleg B. Chakchir
Format: Article
Language:English
Published: F1000 Research Ltd 2018-07-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-57/v2

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https://f1000research.com/articles/7-57/v2

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