B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma
Increasing evidences have demonstrated that B7-H4 is associated with tumor development and prognosis. However, the clinical significance of B7-H4 expression in human osteosarcoma (OS) remains unclear. The aim of present study was to examine the B7-H4 expression and to explore its contribution in OS....
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doaj-61ad0943ae424f4b8cc88326d7a1dc532020-11-24T23:54:51ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/156432156432B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with OsteosarcomaQiang Dong0Xinlong Ma1Department of Orthopedics, Tianjin Hospital, Tianjin Medical University, Tianjin 300211, ChinaDepartment of Orthopedics, Tianjin Hospital, Tianjin Medical University, Tianjin 300211, ChinaIncreasing evidences have demonstrated that B7-H4 is associated with tumor development and prognosis. However, the clinical significance of B7-H4 expression in human osteosarcoma (OS) remains unclear. The aim of present study was to examine the B7-H4 expression and to explore its contribution in OS. B7-H4 expression in OS tissues was examined by immunohistochemistry. Soluble B7-H4 (sB7-H4) levels in blood were examined by ELISA. The association of B7-H4 expression with clinicopathological factors or prognosis was statistically analyzed. Our findings demonstrated that B7-H4 expression in OS tissues was significantly higher than those in paired normal bone tissues (P<0.001). sB7-H4 level in OS serum samples was significantly higher than that in healthy controls (P=0.005). High B7-H4 expression in tissues and sB7-H4 level were both correlated with advanced tumor stage (P<0.001, P=0.017, resp.) and distant metastasis (P=0.034, P=0.021, resp.). Additionally, high B7-H4 expression or serum sB7-H4 levels were significantly related to poor overall survival (P=0.028, P=0.005, resp.). B7-H4 in tissues and serum samples were an independent factor for affecting the survival time of OS patients (P=0.004, P=0.041, resp.). Collectively, our data suggest that the evaluation of B7-H4 expression in tissues and blood is a useful tool for predicting the progression of osteosarcoma and prognosis.http://dx.doi.org/10.1155/2015/156432 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiang Dong Xinlong Ma |
spellingShingle |
Qiang Dong Xinlong Ma B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma BioMed Research International |
author_facet |
Qiang Dong Xinlong Ma |
author_sort |
Qiang Dong |
title |
B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma |
title_short |
B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma |
title_full |
B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma |
title_fullStr |
B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma |
title_full_unstemmed |
B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma |
title_sort |
b7-h4 expression is associated with tumor progression and prognosis in patients with osteosarcoma |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Increasing evidences have demonstrated that B7-H4 is associated with tumor development and prognosis. However, the clinical significance of B7-H4 expression in human osteosarcoma (OS) remains unclear. The aim of present study was to examine the B7-H4 expression and to explore its contribution in OS. B7-H4 expression in OS tissues was examined by immunohistochemistry. Soluble B7-H4 (sB7-H4) levels in blood were examined by ELISA. The association of B7-H4 expression with clinicopathological factors or prognosis was statistically analyzed. Our findings demonstrated that B7-H4 expression in OS tissues was significantly higher than those in paired normal bone tissues (P<0.001). sB7-H4 level in OS serum samples was significantly higher than that in healthy controls (P=0.005). High B7-H4 expression in tissues and sB7-H4 level were both correlated with advanced tumor stage (P<0.001, P=0.017, resp.) and distant metastasis (P=0.034, P=0.021, resp.). Additionally, high B7-H4 expression or serum sB7-H4 levels were significantly related to poor overall survival (P=0.028, P=0.005, resp.). B7-H4 in tissues and serum samples were an independent factor for affecting the survival time of OS patients (P=0.004, P=0.041, resp.). Collectively, our data suggest that the evaluation of B7-H4 expression in tissues and blood is a useful tool for predicting the progression of osteosarcoma and prognosis. |
url |
http://dx.doi.org/10.1155/2015/156432 |
work_keys_str_mv |
AT qiangdong b7h4expressionisassociatedwithtumorprogressionandprognosisinpatientswithosteosarcoma AT xinlongma b7h4expressionisassociatedwithtumorprogressionandprognosisinpatientswithosteosarcoma |
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